What type of cell death occurs in chronic cerebral hypoperfusion? A review focusing on pyroptosis and its potential therapeutic implications

Frontiers in Cellular Neuroscience

Cellular Neuroscience

Min Wu¹  Xi Chen¹  Xianhua Hou¹  Zhenhua Zhou¹  Yuxuan He² 

[1] Department of Neurology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China;Department of Neurology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China;Department of Neurology, School of Medicine, Chongqing University, Chongqing, China;

关键词: pyroptosis;    chronic cerebral hypoperfusion;    therapeutic implications;    inflammasome;    inflammatory cytokine;    review;   

DOI  :  10.3389/fncel.2023.1073511

 received in 2022-10-18, accepted in 2023-01-31,  发布年份 2023

来源: Frontiers

【 摘 要 】

Chronic cerebral hypoperfusion (CCH) is a major global disease with chronic cerebral blood flow reduction. It is also the main cause of cognitive impairment and neurodegenerative diseases. Pyroptosis, a novel form of cell death, is characterized by the rupture of the cell membrane and the release of pro-inflammatory mediators. In recent years, an increasing number of studies have identified the involvement of pyroptosis and its mediated inflammatory response in the pathological process of CCH. Therefore, preventing the activation of pyroptosis following CCH is beneficial to inhibit the inflammatory cascade and reduce brain injury. In this review, we discuss the research progress on the relationship between pyroptosis and CCH, in order to provide a reference for research in related fields.

【 授权许可】

Unknown   
Copyright © 2023 He, Chen, Wu, Hou and Zhou.