White matter microstructural alterations in patients with neuropathic pain after spinal cord injury: a diffusion tensor imaging study

Frontiers in Neurology

Neurology

Youichi Saitoh¹  Haruhiko Kishima²  Koichi Hosomi²  Nobuhiko Mori²  Dong Dong³  Yu-ichiro Ohnishi⁴  Yoshiyuki Watanabe⁵  Takeshi Nakamura⁶  Daisuke Yamagami⁷  Fumihiro Tajima⁸  Yohei Furotani⁸  Yoshi-ichiro Kamijo⁹ 

[1] Department of Mechanical Science and Bioengineering, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka, Japan;Tokuyukai Rehabilitation Clinic, Toyonaka, Osaka, Japan;Department of Neurosurgery, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan;Department of Neurosurgery, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan;Department of Mechanical Science and Bioengineering, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka, Japan;Department of Neurosurgery, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan;Department of Neurosurgery, Osaka Gyoumeikan Hospital, Osaka, Japan;Department of Radiology, Shiga University of Medical Science, Otsu, Shiga, Japan;Department of Rehabilitation Medicine, Graduate School of Medicine, Yokohama City University, Yokohama, Kanagawa, Japan;Department of Rehabilitation Medicine, Graduate School of Medicine, Yokohama City University, Yokohama, Kanagawa, Japan;Department of Rehabilitation Medicine, Kanagawa Rehabilitation Hospital, Atsugi, Kanagawa, Japan;Department of Rehabilitation Medicine, Wakayama Medical University, Wakayama, Japan;Department of Rehabilitation Medicine, Wakayama Medical University, Wakayama, Japan;Department of Rehabilitation Medicine, Saitama Medical Center, Dokkyo Medical University, Mibu, Tochigi, Japan;

关键词: neuropathic pain;    spinal cord injury;    diffusion tensor imaging;    white matter microstructural alterations;    corpus callosum;   

DOI  :  10.3389/fneur.2023.1241658

 received in 2023-06-17, accepted in 2023-08-08,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundThrough contrastive analysis, we aimed to identify the white matter brain regions that show microstructural changes in patients with neuropathic pain (NP) after spinal cord injury (SCI).MethodsWe categorized patients with SCI into NP (n = 30) and non-NP (n = 15) groups. We extracted diffusion tensor maps of fractional anisotropy (FA) and mean (MD), axial (AD), and radial (RD) diffusivity. A randomization-based method in tract-based spatial statistics was used to perform voxel-wise group comparisons among the FA, MD, AD, and RD for nonparametric permutation tests.ResultsAtlas-based analysis located significantly different regions (p < 0.05) in the appointed brain atlas. Compared to the non-NP group, the NP group showed higher FA in the posterior body and splenium of the corpus callosum and higher AD in the corpus callosum, internal capsule, corona radiata, posterior thalamic radiation, sagittal stratum, external capsule, cingulum, fornix/stria terminalis, superior longitudinal fasciculus, and uncinate fasciculus.ConclusionThe results demonstrated that compared with the non-NP group, NP pathogenesis after SCI was potentially related to higher values in FA that are associated with microstructural changes in the posterior body and splenium of the corpus callosum, which could be regarded as central sensitization or network hyperexcitability.

【 授权许可】

Unknown   
Copyright © 2023 Dong, Hosomi, Mori, Kamijo, Furotani, Yamagami, Ohnishi, Watanabe, Nakamura, Tajima, Kishima and Saitoh.