Large animal models of human cauda equina injury and repair: evaluation of a novel goat model

Neural Regeneration Research

关键词: nerve regeneration;    spinal cord injury;    goat;    animal model;    radiography;    magnetic resonance imaging;    diffusion tensor imaging;    fiber bundle;    diagnosis;    injury;    physiology;    neuroimaging;    NSFC grants;    neural regeneration;   

DOI  :  10.4103/1673-5374.150707

来源: DOAJ

【 摘 要 】

Previous animal studies of cauda equina injury have primarily used rat models, which display significant differences from humans. Furthermore, most studies have focused on electrophysiological examination. To better mimic the outcome after surgical repair of cauda equina injury, a novel animal model was established in the goat. Electrophysiological, histological and magnetic resonance imaging methods were used to evaluate the morphological and functional outcome after cauda equina injury and end-to-end suture. Our results demonstrate successful establishment of the goat experimental model of cauda equina injury. This novel model can provide detailed information on the nerve regenerative process following surgical repair of cauda equina injury.

【 授权许可】

Unknown