Erectile function, urinary continence and oncologic outcomes of neurovascular bundle sparing robot-assisted radical prostatectomy for high-risk prostate cancer: A systematic review and meta-analysis

Frontiers in Oncology

Oncology

Jiao Qin¹  Yu Jiang²  Yang Liu³  Li Wang³  Zhi Wen³  Jing Huang³  Cai-xia Chen³  Xue-song Yang³  Chong-jian Wang³  Jia-hao Wang³  Xian-zhong Deng⁴  Kun-peng Li⁵ 

[1] Department of Anesthesia, Affiliated Hospital of North Sichuan Medical College, Nanchong, China;Department of Radiate, Affiliated Hospital of North Sichuan Medical College, Nanchong, China;Department of Urology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China;Department of Urology, Chengdu Xinhua Hospital Affiliated to North Sichuan Medical College, Chengdu, China;Department of Urology, Lanzhou University Second Hospital, Lanzhou, China;

关键词: high-risk prostate cancer;    robot-assisted radical prostatectomy;    neurovascular bundle;    outcomes;    continence;    meta-analysis;   

DOI  :  10.3389/fonc.2023.1161544

 received in 2023-02-08, accepted in 2023-03-23,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundThe nerve-sparing (NS) effect of robot-assisted radical prostatectomy (RARP) on patients with a high-risk prostate cancer remains unclear. The objective of this study was to compare the urinary continence, erectile function and oncology outcomes of the nerve-sparing and non-nerve-sparing (NNS) group during RARP surgeries.MethodsWe systematically searched databases including PubMed, Embase, Cochrane Library and Web of Science to identify relevant studies published in English up to December 2022. Newcastle-Ottawa Scale (NOS) was used as a quality evaluation tool to evaluate the quality of the literature parameters involved, including urinary continence, erectile function and oncologic outcomes, which were compared using the Stata 15.1 software (StataSE, USA).ResultsA total of 8 cohort studies involving 2499 patients were included. A meta-analysis of results showed that the NS group was beneficial to the recovery of urinary continence (RR 0.46, 95%CI 0.22, 0.96; p=0.045<0.05) and erectile function (RR 0.32, 95%CI 0.16, 0.63; p=0.001<0.05) 12 months after surgeries, which showed a better oncological outcome (RR 1.31, 95%CI 1.01, 1.69; p=0.01<0.05).ConclusionsThe current study results indicate that intraoperative NS during RARP is beneficial to long-term postoperative functional recovery and tumor prognosis of patients with high-risk prostate cancers. Due to interstudy interferences, the results should be interpreted with caution.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42022384647.

【 授权许可】

Unknown   
Copyright © 2023 Liu, Deng, Qin, Wen, Jiang, Huang, Wang, Chen, Wang, Li, Wang and Yang