The role of the respiratory microbiome in asthma

Frontiers in Allergy

Allergy

Christina D. Campbell¹  Margaret Gleeson¹  Imran Sulaiman² 

[1] Department of Respiratory Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland;Department of Respiratory Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland;Department of Respiratory Medicine, Beaumont Hospital, Dublin, Ireland;

关键词: asthma;    microbiome;    respiratory microbiome;    biologic therapy;    childhood asthma;   

DOI  :  10.3389/falgy.2023.1120999

 received in 2022-12-10, accepted in 2023-04-13,  发布年份 2023

来源: Frontiers

【 摘 要 】

Asthma is a common airways disease and the human microbiome plays an increasingly recognised role in asthma pathogenesis. Furthermore, the respiratory microbiome varies with asthma phenotype, endotype and disease severity. Consequently, asthma therapies have a direct effect on the respiratory microbiome. Newer biological therapies have led to a significant paradigm shift in how we treat refractory Type 2 high asthma. While airway inflammation is the generally accepted mechanism of action of all asthma therapies, including both inhaled and systemic therapies, there is evidence to suggest that they may also alter the microbiome to create a more functionally balanced airway microenvironment while also influencing airway inflammation directly. This downregulated inflammatory cascade seen biochemically, and reflected in improved clinical outcomes, supports the hypothesis that biological therapies may in fact affect the microbiome-host immune system dynamic and thus represent a therapeutic target for exacerbations and disease control.

【 授权许可】

Unknown   
© 2023 Campbell, Gleeson and Sulaiman.