Risk of SARS-CoV-2 transmission in the close contacts in a small rural area in the Veneto Region (NE-Italy): past evidence for future scenarios

Frontiers in Public Health

Public Health

Andrea Gambaro¹  Marco Bassanello²  Ugo Coli³  Erminio Bonsembiante⁴  Ruggero Geppini⁵  Tatjana Baldovin⁵  Alessandra Buja⁵  Aldo Farencena⁶  Maurizio D’Aquino⁷ 

[1] Department of Environmental Sciences, Informatics and Statistics (DAIS), Ca’ Foscari University of Venice, Venice, Italy;Emergency and Health Department, Monastier di Treviso Hospital, Treviso, Italy;Hygiene and Public Health Unit, Department of Cardiac, Thoracic and Vascular Sciences, School of Medicine and Surgery, University of Padua, Padua, Italy;Health Department, Monastier di Treviso Hospital, Treviso, Italy;Hygiene and Preventive Medicine Service Ulss 2 Marca Trevigiana, Treviso, Italy;Hygiene and Public Health Unit, Department of Cardiac, Thoracic and Vascular Sciences, School of Medicine and Surgery, University of Padua, Padua, Italy;Laboratory and Microbiology Monastier di Treviso Hospital, Treviso, Italy;Medical Department Monastier di Treviso Hospital, Treviso, Italy;

关键词: SARS-CoV-2;    COVID-19;    immunity;    risk for transmission;    social contacts;    non-pharmaceutical interventions;   

DOI  :  10.3389/fpubh.2023.1223109

 received in 2023-05-15, accepted in 2023-08-14,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundDuring the first pandemic phase of COVID-19, an epidemiological study, named First survey, was conducted on the population of a small rural area in northern Italy. In spring 2020, the results showed how a prolonged lockdown slowed down the spread of the virus.MethodsAfter contacting positive First Survey subjects and their families, those who decided to join voluntarily underwent a blood test to assess the presence of qualitative lgG about 2 months after the previous one. This was to determine if IgG persisted in individuals who tested positive in the First Survey as well as to assess the antibody status of their close family members, to determine if they were unintentionally infected.ResultsBased on serological analysis, 35.1% of the samples contained blood IgG. In subjects who tested positive during the First Survey, 62.5% remained IgG positive more than 2 months later. Among family members who were exposed to a positive relative, 23.7% were infected. Linear regression analysis showed that the presence of an infected person within a household resulted in the infection spreading to the others, but not excessively. Induced isolation extinguished the infection regardless of the extent of the contagion (intra-family or extra-family). Micro-outbreaks of SARS-Cov-2 infection which arose in the same household from extra-familial infections played a decisive role on the statistical significance of IgG-positive subjects (p < 0.001).DiscussionThe study reveal 52.6% of the IgG-positive subjects in the Second Survey came from the First Survey and 47.4% were family members previously in contact with positive subjects. Data suggest that there have been undiagnosed patients feeding the spread of the virus since the beginning of the pandemic. In conclusion, for future pandemics, it will be necessary: i) to ensure the rapid isolation of symptomatic patients and the early identification of their close contacts, ii) to carry out the maximum number of tests in the shortest possible time, both on symptomatic and asymptomatic subjects, and iii) to implement information campaigns to make people aware of their risks, and implement clear, non-conflicting communication.

【 授权许可】

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Copyright © 2023 Bassanello, Geppini, Bonsembiante, Coli, Farencena, D’Aquino, Gambaro, Buja and Baldovin.