Cardiovascular hemodynamics in mice with tumor necrosis factor receptor—associated factor 2 mediated cytoprotection in the heart

Frontiers in Cardiovascular Medicine

Cardiovascular Medicine

Jamaine Davis¹  Edgar Garza-Lopez²  Steven Damo³  Thuy T. Pham⁴  Jose A. Gomez⁵  Elsie Spencer⁶  Larry Vang⁶  Taylor Barongan⁶  Zer Vue⁶  Andrea G. Marshall⁶  Zoe Evans⁶  Amber Crabtree⁶  Heather K. Beasley⁶  Kit Neikirk⁶  Josephs Anudokem⁷  Remi Parker⁷  Dominique Stephens⁸  Dao-fu Dai⁹  Vernat Exil^1,10 

[1] Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN, United States;Department of Internal Medicine, University of Iowa, Iowa City, IA, United States;Department of Life and Physical Sciences, Fisk University, Nashville, TN, United States;Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX, United States;Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States;Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, United States;Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, United States;Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN, United States;Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, United States;Department of Life and Physical Sciences, Fisk University, Nashville, TN, United States;Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA, United States;Department of Pediatrics, Div. of Cardiology, St. Louis University School of Medicine, St. Louis, MO, United States;Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA, United States;

关键词: systolic and diastolic function;    myocardial performance index;    ventricular-vascular coupling;    arterial and left ventricular elastance;    aortic impedance;   

DOI  :  10.3389/fcvm.2023.1064640

 received in 2022-10-16, accepted in 2023-04-03,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionMany studies in mice have demonstrated that cardiac-specific innate immune signaling pathways can be reprogrammed to modulate inflammation in response to myocardial injury and improve outcomes. While the echocardiography standard parameters of left ventricular (LV) ejection fraction, fractional shortening, end-diastolic diameter, and others are used to assess cardiac function, their dependency on loading conditions somewhat limits their utility in completely reflecting the contractile function and global cardiovascular efficiency of the heart. A true measure of global cardiovascular efficiency should include the interaction between the ventricle and the aorta (ventricular-vascular coupling, VVC) as well as measures of aortic impedance and pulse wave velocity.MethodsWe measured cardiac Doppler velocities, blood pressures, along with VVC, aortic impedance, and pulse wave velocity to evaluate global cardiac function in a mouse model of cardiac-restricted low levels of TRAF2 overexpression that conferred cytoprotection in the heart.ResultsWhile previous studies reported that response to myocardial infarction and reperfusion was improved in the TRAF2 overexpressed mice, we found that TRAF2 mice had significantly lower cardiac systolic velocities and accelerations, diastolic atrial velocity, aortic pressures, rate-pressure product, LV contractility and relaxation, and stroke work when compared to littermate control mice. Also, we found significantly longer aortic ejection time, isovolumic contraction and relaxation times, and significantly higher mitral early/atrial ratio, myocardial performance index, and ventricular vascular coupling in the TRAF2 overexpression mice compared to their littermate controls. We found no significant differences in the aortic impedance and pulse wave velocity.DiscussionWhile the reported tolerance to ischemic insults in TRAF2 overexpression mice may suggest enhanced cardiac reserve, our results indicate diminished cardiac function in these mice.

【 授权许可】

Unknown   
© 2023 Marshall, Neikirk, Vue, Beasley, Garza-Lopez, Vang, Barongan, Evans, Crabtree, Spencer, Anudokem, Parker, Davis, Stephens, Damo, Pham, Gomez, Exil, Dai, Murray, Entman, Taffet, Hinton and Reddy.