Aerobic Versus Resistance Training Effects on Ventricular-Arterial Coupling and Vascular Function in the STRRIDE-AT/RT Trial

Frontiers in Cardiovascular Medicine

卷:8

Daniel R. Bensimhon¹  Lori A. Bateman²  Brian D. Duscha³  Gregory P. Samsa³  Carolyn L. Lekavich³  Cris A. Slentz³  Aarti A. Kenjale³  Jason D. Allen⁴  Pamela S. Douglas⁵  William E. Kraus⁶ 

[1] Cone Health and Vascular Center, Greensboro, NC, United States;

[2] Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States;

[3] Division of Cardiology, Duke University School of Medicine, Durham, NC, United States;

[4] Division of Cardiovascular Medicine, Department of Kinesiology, University of Virginia, Charlottesville, VA, United States;

[5] Duke Clinical Research Institute, Durham, NC, United States;

[6] Duke Molecular Physiology Institute, Durham, NC, United States;

关键词: heart failure with preserved ejection fraction;    ventricular-arterial coupling;    brachial artery flow mediated dilatation;    echocardiographic imaging;    aerobic vs. resistance exercise training;    ventricular-vascular coupling;   

DOI  :  10.3389/fcvm.2021.638929

来源: DOAJ

【 摘 要 】

Background: The goal was studying the differential effects of aerobic training (AT) vs. resistance training (RT) on cardiac and peripheral arterial capacity on cardiopulmonary (CP) and peripheral vascular (PV) function in sedentary and obese adults.Methods: In a prospective randomized controlled trial, we studied the effects of 6 months of AT vs. RT in 21 subjects. Testing included cardiac and vascular ultrasoundography and serial CP for ventricular-arterial coupling (Ees/Ea), strain-based variables, brachial artery flow-mediated dilation (BAFMD), and peak VO2 (pVO2; mL/kg/min) and peak O2-pulse (O2p; mL/beat).Results: Within the AT group (n = 11), there were significant increases in rVO2 of 4.2 mL/kg/min (SD 0.93) (p = 0.001); O2p of 1.9 mL/beat (SD 1.3) (p = 0.008) and the brachial artery post-hyperemia peak diameter 0.18 mm (SD 0.08) (p = 0.05). Within the RT group (n = 10) there was a significant increase in left ventricular end diastolic volume 7.0 mL (SD 9.8; p = 0.05) and percent flow-mediated dilation (1.8%) (SD 0.47) (p = 0.004). Comparing the AT and RT groups, post exercise, rVO2 2.97, (SD 1.22), (p = 0.03), O2p 0.01 (SD 1.3), (p = 0.01), peak hyperemic blood flow volume (1.77 mL) (SD 140.69) (p = 0.009), were higher in AT, but LVEDP 115 mL (SD 7.0) (p = 0.05) and Ees/Ea 0.68 mmHg/ml (SD 0.60) p = 0.03 were higher in RT.Discussion: The differential effects of AT and RT in this hypothesis generating study have important implications for exercise modality and clinical endpoints.

【 授权许可】

Unknown