Effect of fruit on glucose control in diabetes mellitus: a meta-analysis of nineteen randomized controlled trials

Frontiers in Endocrinology

Endocrinology

Chenfei Ying¹  Hua Luo¹  Yongwei Su²  Yu Ren³  Shuang Sun⁴ 

[1] Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China;Department of Orthopedic, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China;Department of Pharmacy, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China;Key Laboratory of Pathobiology, Ministry of Education, Nanomedicine and Translational Research Center, The Third Bethune Hospital of Jilin University, Changchun, Jilin, China;

关键词: fruit;    glucose;    diabetes;    glycosylated hemoglobin;    meta-analaysis;   

DOI  :  10.3389/fendo.2023.1174545

 received in 2023-02-26, accepted in 2023-04-10,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectiveDiabetes mellitus is a worldwide health problem, and it remains unclarified whether fruit is beneficial in glycemic control. This study aimed to analyze evidence from randomized controlled trials evaluating the effect of fruit consumption on glucose control.MethodsWe searched the PubMed, EMBASE, Ovid, Web of Science, and Cochrane Central Register of Controlled Trials databases from the respective database inception dates to December 30, 2022, to identify randomized controlled trials that evaluated the effects of fruit consumption on glucose control. Two researchers independently screened the studies in accordance with the inclusion and exclusion criteria, and performed the literature quality evaluation and data extraction. RevMan 5.4 software was used to perform the data analysis.ResultsNineteen randomized controlled trials with 888 participants were included. Fruit consumption significantly decreased the fasting blood glucose concentration (MD -8.38, 95% CI -12.34 to -4.43), but it showed no significant difference in the glycosylated hemoglobin (MD -0.17, 95% CI -0.51 to 0.17). Subgroup analyses further suggested that the consumption of both fresh and dried fruit decreased the fasting blood glucose concentration.ConclusionsIncreasing the fruit intake reduced fasting blood glucose concentration. Therefore, we recommend that patients with diabetes eat more fruits while ensuring that their total energy intake remains unchanged.

【 授权许可】

Unknown   
Copyright © 2023 Ren, Sun, Su, Ying and Luo