The Influence of Aging on the Functional Connectivity of the Human Basal Ganglia

Frontiers in Aging Neuroscience

Aging Neuroscience

Clara Rodriguez-Sabate¹  Manuel Rodriguez¹  Ingrid Morales¹ 

[1] Center for Networked Biomedical Research in Neurodegenerative Diseases, Madrid, Spain;Laboratory of Neurobiology and Experimental Neurology, Department of Basic Medical Sciences, Physiology, Faculty of Medicine, University of La Laguna, San Cristóbal de La Laguna, Spain;

关键词: aging;    basal ganglia;    functional connectivity;    hand motion;    resting state;   

DOI  :  10.3389/fnagi.2021.785666

 received in 2021-09-29, accepted in 2021-12-14,  发布年份 2022

来源: Frontiers

【 摘 要 】

Although basal ganglia (BG) are involved in the motor disorders of aged people, the effect of aging on the functional interaction of BG is not well-known. This work was aimed at studying the influence of aging on the functional connectivity of the motor circuit of BG (BGmC). Thirty healthy volunteers were studied (young-group 26.4 ± 5.7 years old; aged-group 63.1 ± 5.8 years old) with a procedure planned to prevent the spurious functional connectivity induced by the closed-loop arrangement of the BGmC. BG showed different functional interactions during the inter-task intervals and when subjects did not perform any voluntary task. Aging induced marked changes in the functional connectivity of the BGmC during these inter-task intervals. The finger movements changed the functional connectivity of the BG, these modifications were also different in the aged-group. Taken together, these data show a marked effect of aging on the functional connectivity of the BGmC, and these effects may be at the basis of the motor handicaps of aged people during the execution of motor-tasks and when they are not performing any voluntary motor task.

【 授权许可】

Unknown   
Copyright © 2022 Rodriguez-Sabate, Morales and Rodriguez.