The effect of metabolic syndrome on postoperative complications and long-term survival of patients with colorectal cancer

Frontiers in Oncology

Oncology

Ce Zhu¹  Wentao Cai¹  Jian Chen¹  Yaojun Yu¹  Jingwei Zheng¹  Liyi Li¹  Tao You¹  Hui Yang¹  Xian Shen²  Chenchen Mao³ 

[1] Department of Gastrointestinal Surgery, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China;Department of Gastrointestinal Surgery, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China;Department of Gastrointestinal Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China;Department of Microbiology and Immunology, School of Basic Medical Sciences, Institute of Molecular Virology and Immunology, Wenzhou Medical University, Zhejiang, China;

关键词: metabolic syndrome;    colorectal cancer;    overall survival;    postoperative complications;    propensity score matching;   

DOI  :  10.3389/fonc.2023.1036458

 received in 2022-09-04, accepted in 2023-06-09,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundMetabolic syndrome (MetS) is associated with poor prognosis in many cancers. However, the relationship between metabolic syndrome and overall survival (OS) in patients with colorectal cancer (CRC) remains unclear. We aimed to comprehensively analyze whether MetS could affect postoperative complications and long-term survival in patients with CRC.MethodsWe included patients who underwent CRC resection at our center between January 2016 and December 2018. Bias was reduced through propensity score matching analysis. Patients with CRC were divided into the MetS and non-MetS groups based on whether they had MetS. Univariate and multivariate analyses were used to identify risk factors affecting OS.ResultsWe included 268 patients; among them, 120 were included for further analysis after propensity score matching. There were no significant between-group differences in the clinicopathological features after matching. Compared with the non-MetS group, the MetS group had a shorter OS (P = 0.027); however, there was no significant between-group difference in postoperative complications. Multivariate analysis revealed that MetS (hazard ratio [HR] = 1.997, P = 0.042), tumor-node-metastasis stage (HR = 2.422, P = 0.003), and intestinal obstruction (HR = 2.761, P = 0.010) were independent risk factors for OS.ConclusionsMetS affects the long-term survival of patients with CRC without affecting postoperative complications.

【 授权许可】

Unknown   
Copyright © 2023 Zhu, Mao, Cai, Zheng, Yang, You, Chen, Yu, Shen and Li