Clinical significance of the histopathological metastatic largest lymph node size in colorectal cancer patients

Frontiers in Oncology

Oncology

Aziz Serkan Senger¹  Erdal Polat¹  Mustafa Duman¹  Orhan Uzun¹  Selcuk Gulmez¹  Onur Guven²  Ozgur Bostanci²  Sinan Omeroglu² 

[1] Department of Gastrointestinal Surgery, University of Health Sciences Kosuyolu High Specialization Education and Research Hospital, Istanbul, Türkiye;Department of General Surgery, University of Health Sciences Sisli Hamidiye Etfal Research and Training Hospital, Istanbul, Türkiye;

关键词: colorectal cancer;    lymph node metastasis;    lymph node size;    survival;    postoperative complications;   

DOI  :  10.3389/fonc.2023.1120753

 received in 2022-12-10, accepted in 2023-02-09,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundThe metastatic lymph nodes (MLN) are interpreted to be correlated with prognosis of the colorectal cancers (CRC). The present retrospective study aimed to investigate the clinical significance of the largest MLN size in terms of postoperative outcomes and its predictive value in the prognosis of the patients with stage III CRC.MethodsBetween May 2013 and December 2018, a total of 101 patients who underwent curative resection for stage III CRC retrospectively reviewed. All patients were divided into two groups regarding cut-off value (<1.05 cm and ≥1.05 cm) of maximum MLN diameter measured histopathologically. A comparative analysis of demographic and clinicopathological characteristics of the patients and their postoperative outcomes were performed.ResultsTwo groups carried similar demographic data and preoperative laboratory variables except the lymphocyte count, hematocrit (HCT) ratio, hemoglobin level and mean corpuscular volume (MCV) value (p<0.05). The patients with MLN diameter ≥1.05 cm (n=46) needed more erythrocyte suspension and were hospitalized longer than the patients with a diameter <1.05 cm (n=55) (p=0.006 and 0.0294, respectively). Patients with MLN diameter < 1.05 cm had a significantly longer overall survival than patients with MLN diameter ≥ 1.05 cm (75,29 vs. 52,57 months, respectively). Regarding the histopathologic features, the patients with MLN diameter ≥1.05 cm had larger tumor size and higher number of MLN than those with diameter <1.05 cm (p=0.049 and 0.001).ConclusionThe size of MLN larger than 1.05 cm may be predictive for a poor prognosis and lower survival of stage III CRC patients. The largest MLN size may be a proper alternative factor to the number of MLNs in predicting prognosis or in staging CRC patients.

【 授权许可】

Unknown   
Copyright © 2023 Omeroglu, Gulmez, Uzun, Senger, Bostanci, Guven, Polat and Duman