The efficacy of topical aminophylline in local fat reduction: A systematic review

Frontiers in Endocrinology

Endocrinology

Ramin Abdi Dezfouli¹  Mostafa Qorbani²  Ali Hosseinpour³  Elnaz Daneshzad³ 

[1] Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran;Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran;Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran;Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran;

关键词: aminophylline;    topical;    fat reduction;    thigh;    lipolysis;   

DOI  :  10.3389/fendo.2023.1087614

 received in 2022-11-24, accepted in 2023-02-06,  发布年份 2023

来源: Frontiers

【 摘 要 】

Background and aimsSome studies have reported that the topical forms with aminophylline as the active ingredient appear to be relatively effective on local fat burning while having no/minimal side effects. This systematic review accumulates all of the data on the local fat-burning potency of aminophylline topical formulation.MethodsDocuments were retrieved from PubMed, Web of Science, and Scopus databases until Aug 2022. Data were extracted from clinical trials reporting the reduction in thigh or waist circumference as a result of using topical forms containing aminophylline. Screening of included studies was performed independently by two authors and the quality assessment of included studies was performed based on the Cochrane Collaboration’s approach.ResultsOf the 802 initial studies, 5 studies were included in the systematic review. Several concentrations of aminophylline were used in different studies. Most studies administred the topical formulation on participants’ one thigh, and the other thigh was considered to be the control for comparing the fat reduction amount. Except for one study, all other studies reported that all participants lost more fat on the treated area than the control groups. The amount of fat reduction differed in studies regarding their different aminophylline concentrations and administration routines. In the case of side effects, except for some studies reporting skin rashes, other studies reported no significant side effects at all.ConclusionsAminophylline topical formulation offers a safe, effective, and much less invasive alternative to cosmetic surgery for localized fat reduction. It seems that the 0.5% concentration, administered five times a week for five weeks is the most potent concentration. However, more high-quality clinical trials are needed to verify this conclusion.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42022353578.

【 授权许可】

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Copyright © 2023 Abdi Dezfouli, Hosseinpour, Qorbani and Daneshzad