Nutritional Strategies for the Individualized Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) Based on the Nutrient-Induced Insulin Output Ratio (NIOR)

International Journal of Molecular Sciences

Dominika Maciejewska¹  Ewa Stachowska¹  Dominika Jamioł-Milc¹  Marcin Banaszczak¹  Izabela Gutowska¹  Anna Sabinicz¹  Piotr Ossowski¹  Karina Ryterska¹  Małgorzata Kaczorowska¹  Piotr Milkiewicz²  Małgorzata Napierała³  Lidia Wądołowska⁴  Małgorzata Milkiewicz⁵  Joanna Raszeja-Wyszomirska⁶ 

[1] Department of Biochemistry and Human Nutrition, Pomeranian Medical University, Szczecin 71-460, Poland;Department of Clinical and Molecular Biochemistry, Pomeranian Medical University, Szczecin 70-111, Poland;Department of Diabetology and Internal Diseases Pomeranian Medical University, Szczecin 72-010, Poland;Department of Human Nutrition, University of Warmia and Mazury, Olsztyn 10-718, Poland;Department of Medical Biology, Pomeranian Medical University, Szczecin 70-111, Poland;Liver and Internal Medicine Unit, Department of General, Transplant and Liver Surgery of the Medical University of Warsaw, Warsaw 02-097, Poland;

关键词: NAFLD;    NAFLD diet;    insulin sensitivity;    NIOR;    reduction of body mass;    fat reduction;    liver fat;   

DOI  :  10.3390/ijms17071192

来源: DOAJ

【 摘 要 】

Nutrients play a fundamental role as regulators of the activity of enzymes involved in liver metabolism. In the general population, the action of nutrients may be affected by gene polymorphisms. Therefore, individualization of a diet for individuals with fatty liver seems to be a fundamental step in nutritional strategies. In this study, we tested the nutrient-induced insulin output ratio (NIOR), which is used to identify the correlation between the variants of genes and insulin resistance. We enrolled 171 patients, Caucasian men (n = 104) and women (n = 67), diagnosed with non-alcoholic fatty liver disease (NAFLD). From the pool of genes sensitive to nutrient content, we selected genes characterized by a strong response to the NIOR. The polymorphisms included Adrenergic receptor (b3AR), Tumor necrosis factor (TNFα), Apolipoprotein C (Apo C III). Uncoupling Protein type I (UCP-1), Peroxisome proliferator activated receptor γ2 (PPAR-2) and Apolipoprotein E (APOEs). We performed three dietary interventions: a diet consistent with the results of genotyping (NIOR (+)); typical dietary recommendations for NAFLD (Cust (+)), and a diet opposite to the genotyping results (NIOR (−) and Cust (−)). We administered the diet for six months. The most beneficial changes were observed among fat-sensitive patients who were treated with the NIOR (+) diet. These changes included improvements in body mass and insulin sensitivity and normalization of blood lipids. In people sensitive to fat, the NIOR seems to be a useful tool for determining specific strategies for the treatment of NAFLD.

【 授权许可】

Unknown