Ginseng Berry Extract Supplementation Improves Age-Related Decline of Insulin Signaling in Mice

Nutrients

Eunhui Seo²  Sunmi Kim³  Sang Jun Lee³  Byung-Chul Oh¹ 

[1] Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 406-840, Korea; E-Mail:;College of Pharmacy and Gachon Institute of Pharmaceutical Science, Gachon University, Incheon 406-840, Korea; E-Mail:;R & D Center, Amorepacific Corporation, Gyeonggi-do 446-729, Korea; E-Mails:

关键词: ginseng berry;    aging;    insulin sensitivity;   

DOI  :  10.3390/nu7043038

来源: mdpi

【 摘 要 】

The aim of this study was to evaluate the effects of ginseng berry extract on insulin sensitivity and associated molecular mechanisms in aged mice. C57BL/6 mice (15 months old) were maintained on a regular diet (CON) or a regular diet supplemented with 0.05% ginseng berry extract (GBD) for 24 or 32 weeks. GBD-fed mice showed significantly lower serum insulin levels (p = 0.016) and insulin resistance scores (HOMA-IR) (p = 0.012), suggesting that GBD improved insulin sensitivity. Pancreatic islet hypertrophy was also ameliorated in GBD-fed mice (p = 0.007). Protein levels of tyrosine phosphorylated insulin receptor substrate (IRS)-1 (p = 0.047), and protein kinase B (AKT) (p = 0.037), were up-regulated in the muscle of insulin-injected GBD-fed mice compared with CON-fed mice. The expressions of forkhead box protein O1 (FOXO1) (p = 0.036) and peroxisome proliferator-activated receptor gamma (PPARγ) (p = 0.032), which are known as aging- and insulin resistance-related genes, were also increased in the muscle of GBD-fed mice. We conclude that ginseng berry extract consumption might increase activation of IRS-1 and AKT, contributing to the improvement of insulin sensitivity in aged mice.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.