Growth hormone receptor gene disruption in mature‐adult mice improves male insulin sensitivity and extends female lifespan

Aging Cell

Yuji Ikeno¹  Todd McHugh²  Stephen Bell³  Jonathan Young³  Shoshana Yakar⁴  Reetobrata Basu⁵  Kevin Funk⁵  Edward O. List⁵  Samuel Mathes⁵  Yanrong Qian⁵  Silvana Duran‐Ortiz⁶  Darlene E. Berryman⁷  John J. Kopchick⁷  Prateek Kulkarni⁸ 

[1] Barshop Institute for Longevity and Aging Studies, San Antonio, Texas, USA;Department of Biological Sciences, College of Arts and Sciences, Ohio University, Athens, Ohio, USA;Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA;Department of Molecular Pathobiology, David B. Kriser Dental Center, New York University College of Dentistry, New York, New York, USA;Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA;Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA;Molecular and Cellular Biology program, Ohio University, Athens, Ohio, USA;Department of Biological Sciences, College of Arts and Sciences, Ohio University, Athens, Ohio, USA;Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA;Molecular and Cellular Biology program, Ohio University, Athens, Ohio, USA;Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA;Diabetes Institute, Ohio University, Athens, Ohio, USA;Molecular and Cellular Biology program, Ohio University, Athens, Ohio, USA;Department of Biological Sciences, College of Arts and Sciences, Ohio University, Athens, Ohio, USA;

关键词: aging;    Cre‐Lox;    growth hormone;    IGF‐1;    insulin sensitivity;    lifespan;    tamoxifen;   

DOI  :  10.1111/acel.13506

来源: Wiley

【 授权许可】

CC BY