Motor cortical functional connectivity changes due to short-term immobilization of upper limb: an fNIRS case report

Frontiers in Rehabilitation Sciences

Rehabilitation Sciences

Arun Karumattu Manattu¹  Christopher Copeland¹  Kaitlin Fraser¹  Jordan A. Borrell²  Jorge M. Zuniga² 

[1] Department of Biomechanics, University of Nebraska at Omaha, Omaha, NE, United States;Department of Biomechanics, University of Nebraska at Omaha, Omaha, NE, United States;Center for Biomedical Rehabilitation and Manufacturing, University of Nebraska at Omaha, Omaha, NE, United States;

关键词: fNIRS (functional near infrared spectroscopy);    resting state connectivity;    immobilization;    plasticity;    functional reorganization;   

DOI  :  10.3389/fresc.2023.1156940

 received in 2023-02-02, accepted in 2023-04-26,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionA short-term immobilization of one hand affects musculoskeletal functions, and the associated brain network adapts to the alterations happening to the body due to injuries. It was hypothesized that the injury-associated temporary disuse of the upper limb would alter the functional interactions of the motor cortical processes and will produce long-term changes throughout the immobilization and post-immobilization period.MethodsThe case participant (male, 12 years old, right arm immobilized for clavicle fracture) was scanned using optical imaging technology of fNIRS over immobilization and post-immobilization. Pre-task data was collected for 3 min for RSFC analysis, processed, and analyzed using the Brain AnalyzIR toolbox. Connectivity was measured using Pearson correlation coefficients (R) from NIRS Toolbox's connectivity module.ResultsThe non-affected hand task presented an increased ipsilateral response during the immobilization period, which then decreased over the follow-up visits. The right-hand task showed a bilateral activation pattern following immobilization, but the contralateral activation pattern was restored during the 1-year follow-up visit. Significant differences in the average connection strength over the study period were observed. The average Connection strength decreased from the third week of immobilization and continued to be lower than the baseline value. Global network efficiency decreased in weeks two and three, while the network settled into a higher efficient state during the follow-up periods after post-immobilization.DiscussionShort-term immobilization of the upper limb is shown to have cortical changes in terms of activations of brain regions as well as connectivity. The short-term dis-use of the upper limb has shifted the unilateral activation pattern to the bilateral coactivation of the motor cortex from both hemispheres. Resting-state data reveals a disruption in the motor cortical network during the immobilization phase, and the network is reorganized into an efficient network over 1 year after the injury. Understanding such cortical reorganization could be informative for studying the recovery from neurological disorders affecting motor control in the future.

【 授权许可】

Unknown   
© 2023 Karumattu Manattu, Borrell, Copeland, Fraser and Zuniga.