Resting state functional connectivity predicts neurofeedback response

Frontiers in Behavioral Neuroscience

Teodora eStoica¹  Christopher ePittenger¹  Suzanne eWasylink¹  Michelle eHampson¹  John eSaksa¹  Patricia eGruner¹  Dustin eScheinost¹ 

[1] Yale;

关键词: Neurofeedback;    Obsessive-Compulsive Disorder;    orbitofrontal cortex;    real-time fMRI;    resting state connectivity;    rtfMRI;   

DOI  :  10.3389/fnbeh.2014.00338

来源: DOAJ

【 摘 要 】

Tailoring treatments to the specific needs and biology of individual patients – personalized medicine – requires delineation of reliable predictors of response. Unfortunately, these have been slow to emerge, especially in neuropsychiatric disorders. We have recently described a real-time functional magnetic resonance imaging (rt-fMRI) neurofeedback protocol that can reduce contamination-related anxiety, a prominent symptom of many cases of obsessive-compulsive disorder (OCD).Individual response to this intervention is variable.Here we used patterns of brain functional connectivity, as measured by baseline resting-state fMRI (rs-fMRI), to predict improvements in contamination anxiety after neurofeedback training. Activity of a region of the orbitofrontal cortex (OFC) and anterior prefrontal cortex, Brodmann area (BA) 10, associated with contamination anxiety in each subject was measured in real time and presented as a neurofeedback signal, permitting subjects to learn to modulate this target brain region. We have previously reported both enhanced OFC/BA 10 control and improved anxiety in a group of subclinically anxious subjects after neurofeedback.Five individuals with contamination-related OCD who underwent the same protocol also showed improved clinical symptomatology.In both groups, these behavioral improvements were strongly correlated with baseline whole-brain connectivity in the OFC/BA 10, computed from rs-fMRI collected several days prior to neurofeedback training. These pilot data suggest that rs-fMRI can be used to identify individuals likely to benefit from rt-fMRI neurofeedback training to control contamination anxiety.

【 授权许可】

Unknown