PCDH7 as the key gene related to the co-occurrence of sarcopenia and osteoporosis

Frontiers in Genetics

Genetics

Bingdi Chen¹  Jun Li¹  Jingyao Chen¹  Guixin Sun²  Mingchong Liu²  Chensong Yang²  Qidong Wang²  Yongheng Wang³  Wentao Shi³ 

[1] Institute for Regenerative Medicine, Shanghai East Hospital, The Institute for Biomedical Engineering and Nano Science, Tongji University School of Medicine, Shanghai, China;Shanghai East Hospital, School of Medicine, Shanghai, China;Shanghai Tenth People’s Hospital, School of Medicine, Shanghai, China;

关键词: sarcopenia;    osteoporosis;    crosstalk genes;    machine learning;    bioinformatic analysis;   

DOI  :  10.3389/fgene.2023.1163162

 received in 2023-02-10, accepted in 2023-04-06,  发布年份 2023

来源: Frontiers

【 摘 要 】

Sarcopenia and osteoporosis, two degenerative diseases in older patients, have become severe health problems in aging societies. Muscles and bones, the most important components of the motor system, are derived from mesodermal and ectodermal mesenchymal stem cells. The adjacent anatomical relationship between them provides the basic conditions for mechanical and chemical signals, which may contribute to the co-occurrence of sarcopenia and osteoporosis. Identifying the potential common crosstalk genes between them may provide new insights for preventing and treating their development. In this study, DEG analysis, WGCNA, and machine learning algorithms were used to identify the key crosstalk genes of sarcopenia and osteoporosis; this was then validated using independent datasets and clinical samples. Finally, four crosstalk genes (ARHGEF10, PCDH7, CST6, and ROBO3) were identified, and mRNA expression and protein levels of PCDH7 in clinical samples from patients with sarcopenia, with osteoporosis, and with both sarcopenia and osteoporosis were found to be significantly higher than those from patients without sarcopenia or osteoporosis. PCDH7 seems to be a key gene related to the development of both sarcopenia and osteoporosis.

【 授权许可】

Unknown   
Copyright © 2023 Liu, Wang, Shi, Yang, Wang, Chen, Li, Chen and Sun.