Association between Bone Mineral Density and Fat Mass Independent of Lean Mass and Physical Activity in Women Aged 75 or Older

Nutrients

Guillaume Chapelet¹  Anne-Sophie Boureau¹  Laure de Decker¹  Marie Mathieu¹  Typhaine Riaudel¹  Céline Brouessard¹  Gilles Berrut¹  Pascale Guillot² 

[1] Department of Geriatrics, Nantes University Hospital, 44093 Nantes, France;Department of Rheumatology, Nantes University Hospital, 44093 Nantes, France;

关键词: bone mineral density;    lean mass;    fat mass;    osteoporosis;    physical activity level;    sarcopenia;   

DOI  :  10.3390/nu13061994

来源: DOAJ

【 摘 要 】

(1) Osteoporosis and sarcopenia are frequent pathologies among the geriatric population. The interlink between these two diseases is supported by their common pathophysiology. The aim is to explore the relationship between bone mineral density (BMD) and body composition in women aged 75 or older. (2) From January 2016 to December 2019, women aged 75 or older of Caucasian ethnicity, who were addressed to perform a biphoton absorptiometry (DXA), were included in this observational study. Femoral neck T-score, lean mass, fat mass, and physical performances were measured. (3) The mean age of 101 patients included was 84.8 (±4.9) years old. Osteoporosis was present in 72% of patients. According to EWGSOP criteria, 37% of patients were sarcopenic. Osteosarcopenia was present in 34% of patients. The femoral neck T-score was significantly associated with fat mass (β = 0.02, 95% CI (0.01; 0.03), p < 0.05) in multivariable analysis. Osteosarcopenic patients had significantly lower fat mass (16.2 kg (±6.8) vs. 23.1 kg (±10.8), p < 0.001) and body mass index (BMI) (20.7 kg/m² (±2.8) vs. 26.7 kg/m² (±5.6), p < 0.001). (4) In postmenopausal women, fat mass is estimated to provide hormonal protection. While osteosarcopenia is described as a lipotoxic disease, fat mass and BMI would appear to protect against the risk of osteosarcopenia. This raises questions about the relevance of BMI and DXA.

【 授权许可】

Unknown