Adaptive and innate immune pathogenesis of bullous pemphigoid: A review

Frontiers in Immunology

Immunology

Zhenying Zhang¹  Tianmeng Yan² 

[1] Department of Dermatology, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, China;Department of Dermatology, The University of Hong Kong Shenzhen Hospital, Shenzhen, China;

关键词: bullous pemphigoid;    adaptive immunity;    innate immunity;    crosstalk;    pathogenesis;   

DOI  :  10.3389/fimmu.2023.1144429

 received in 2023-01-14, accepted in 2023-02-24,  发布年份 2023

来源: Frontiers

【 摘 要 】

Bullous pemphigoid (BP) is an autoimmune blistering disease that primarily affects elderly individuals. The presentation of BP is heterogeneous, typically manifesting as microscopic subepidermal separation with a mixed inflammatory infiltrate. The mechanism of pemphigoid development is unclear. B cells play a major role in pathogenic autoantibody production, and T cells, type II inflammatory cytokines, eosinophils, mast cells, neutrophils, and keratinocytes are also implicated in the pathogenesis of BP. Here, we review the roles of and crosstalk between innate and adaptive immune cells in BP.

【 授权许可】

Unknown   
Copyright © 2023 Yan and Zhang