What Is IL-1 for? The Functions of Interleukin-1 Across Evolution

Frontiers in Immunology

Diana Boraschi³ 

[1] Institute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), Napoli, Italy;Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Science (CAS), Shenzhen, China;Stazione Zoologica Anton Dohrn, Napoli, Italy;

关键词: interleukin-1;    inflammation;    innate immunity;    adaptive immunity;    evolution;   

DOI  :  10.3389/fimmu.2022.872155

来源: DOAJ

【 摘 要 】

Interleukin-1 is a cytokine with potent inflammatory and immune-amplifying effects, mainly produced by macrophages during defensive reactions. In mammals, IL-1 is a superfamily of eleven structurally similar proteins, all involved in inflammation or its control, which mainly act through binding to specific receptors on the plasma membrane of target cells. IL-1 receptors are also a family of ten structurally similar transmembrane proteins that assemble in heterocomplexes. In addition to their innate immune/inflammatory effects, the physiological role of IL-1 family cytokines seems to be linked to the development of adaptive immunity in vertebrates. We will discuss why IL-1 developed in vertebrates and what is its physiological role, as a basis for understanding when and how it can be involved in the initiation and establishment of pathologies.

【 授权许可】

Unknown