Enhanced antibacterial and anticancer activities of plant extract mediated green synthesized zinc oxide-silver nanoparticles

Frontiers in Microbiology

Microbiology

Jactty Chew¹  Sin-Yeang Teow²  Michiele Lee-Kiun Soon³  Nur Afini Ismail⁴  Siti Nur Amalina Mohamad Sukri⁴  Li-Ting Ooi⁵  Hassan Moeini⁶  Kamyar Shameli⁶ 

[1] Department of Biological Sciences, School of Medical and Life Sciences, Sunway University, Bandar Sunway, Selangor, Malaysia;Department of Biology, College of Science, Mathematics and Technology, Wenzhou-Kean University, Wenzhou, Zhejiang, China;Department of Medical Sciences, School of Medical and Life Sciences, Sunway University, Bandar Sunway, Selangor, Malaysia;Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia, Kuala Lumpur, Malaysia;School of Health Sciences, International Medical University, Kuala Lumpur, Malaysia;School of Medicine, Institute of Virology, Technical University of Munich, Munich, Germany;

关键词: zinc oxide;    silver;    nanoparticles;    green synthesis;    Punica granatum;    antibacterial;    anticancer;   

DOI  :  10.3389/fmicb.2023.1194292

 received in 2023-03-26, accepted in 2023-07-10,  发布年份 2023

来源: Frontiers

【 摘 要 】

This study presents a green synthesis approach for the fabrication of zinc oxide-silver nanoparticles (ZnO-Ag-NPs) using Punica granatum fruit peels extract as a natural reducing and stabilizing agent. This eco-friendly method offers a sustainable alternative to conventional methods that often employ toxic or hazardous chemicals. Antibacterial and anti-cancer activities of the green synthesized nanoparticles were then assessed in vitro. X-ray diffraction confirmed the production of ZnO-Ag-NPs with increasing crystallinity in higher pH values. The ZnO-Ag-NPs were found to be agglomerated with spherical Ag-NPs. Fourier Transform Infrared (FTIR) spectra revealed a broad band in ZnO-Ag-NPs ranging from 400−1 to 530 cm−1 with reduced intensity as compared to ZnO-NPs, indicating the formation of Ag-NPs on the surface of ZnO-NPs. The synthesized ZnO-Ag-NPs exhibited potent antibacterial activity against a broad spectrum of bacterial strains, particularly Gram-positive bacteria, with superior inhibition activity compared to ZnO-NPs. Moreover, ZnO-Ag-NPs showed a dose-dependent anti-proliferative effect on colorectal-, lung-, and cervical cancer cells. ZnO-Ag-NPs showed significantly greater efficacy in inhibiting cancer cell growth at a lower concentration of 31.25 μg/mL, compared to ZnO-NPs which required over 500 μg/mL, possibly due to the presence of silver nanoparticles (Ag-NPs). The results obtained from this study demonstrate the potential of green synthesis approaches in the fabrication of therapeutic nanomaterials for cancer treatment, as well as other biomedical applications.

【 授权许可】

Unknown   
Copyright © 2023 Mohamad Sukri, Shameli, Teow, Chew, Ooi, Lee-Kiun Soon, Ismail and Moeini.