Frontiers in Microbiology | |
Enhanced antibacterial and anticancer activities of plant extract mediated green synthesized zinc oxide-silver nanoparticles | |
Microbiology | |
Jactty Chew1  Sin-Yeang Teow2  Michiele Lee-Kiun Soon3  Nur Afini Ismail4  Siti Nur Amalina Mohamad Sukri4  Li-Ting Ooi5  Hassan Moeini6  Kamyar Shameli6  | |
[1] Department of Biological Sciences, School of Medical and Life Sciences, Sunway University, Bandar Sunway, Selangor, Malaysia;Department of Biology, College of Science, Mathematics and Technology, Wenzhou-Kean University, Wenzhou, Zhejiang, China;Department of Medical Sciences, School of Medical and Life Sciences, Sunway University, Bandar Sunway, Selangor, Malaysia;Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia, Kuala Lumpur, Malaysia;School of Health Sciences, International Medical University, Kuala Lumpur, Malaysia;School of Medicine, Institute of Virology, Technical University of Munich, Munich, Germany; | |
关键词: zinc oxide; silver; nanoparticles; green synthesis; Punica granatum; antibacterial; anticancer; | |
DOI : 10.3389/fmicb.2023.1194292 | |
received in 2023-03-26, accepted in 2023-07-10, 发布年份 2023 | |
来源: Frontiers | |
【 摘 要 】
This study presents a green synthesis approach for the fabrication of zinc oxide-silver nanoparticles (ZnO-Ag-NPs) using Punica granatum fruit peels extract as a natural reducing and stabilizing agent. This eco-friendly method offers a sustainable alternative to conventional methods that often employ toxic or hazardous chemicals. Antibacterial and anti-cancer activities of the green synthesized nanoparticles were then assessed in vitro. X-ray diffraction confirmed the production of ZnO-Ag-NPs with increasing crystallinity in higher pH values. The ZnO-Ag-NPs were found to be agglomerated with spherical Ag-NPs. Fourier Transform Infrared (FTIR) spectra revealed a broad band in ZnO-Ag-NPs ranging from 400−1 to 530 cm−1 with reduced intensity as compared to ZnO-NPs, indicating the formation of Ag-NPs on the surface of ZnO-NPs. The synthesized ZnO-Ag-NPs exhibited potent antibacterial activity against a broad spectrum of bacterial strains, particularly Gram-positive bacteria, with superior inhibition activity compared to ZnO-NPs. Moreover, ZnO-Ag-NPs showed a dose-dependent anti-proliferative effect on colorectal-, lung-, and cervical cancer cells. ZnO-Ag-NPs showed significantly greater efficacy in inhibiting cancer cell growth at a lower concentration of 31.25 μg/mL, compared to ZnO-NPs which required over 500 μg/mL, possibly due to the presence of silver nanoparticles (Ag-NPs). The results obtained from this study demonstrate the potential of green synthesis approaches in the fabrication of therapeutic nanomaterials for cancer treatment, as well as other biomedical applications.
【 授权许可】
Unknown
Copyright © 2023 Mohamad Sukri, Shameli, Teow, Chew, Ooi, Lee-Kiun Soon, Ismail and Moeini.
【 预 览 】
Files | Size | Format | View |
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RO202310106091715ZK.pdf | 3917KB | download |