期刊论文详细信息
Frontiers in Neural Circuits
Spinal cords: Symphonies of interneurons across species
Neuroscience
Alexia C. Wilson1  Lora B. Sweeney2 
[1] Institute of Science and Technology Austria (IST Austria), Klosterneuburg, Lower Austria, Austria;null;
关键词: spinal cord;    interneuron;    motor control;    vertebrate evolution;    movement;    cross-species comparison;   
DOI  :  10.3389/fncir.2023.1146449
 received in 2023-01-17, accepted in 2023-03-23,  发布年份 2023
来源: Frontiers
PDF
【 摘 要 】

Vertebrate movement is orchestrated by spinal inter- and motor neurons that, together with sensory and cognitive input, produce dynamic motor behaviors. These behaviors vary from the simple undulatory swimming of fish and larval aquatic species to the highly coordinated running, reaching and grasping of mice, humans and other mammals. This variation raises the fundamental question of how spinal circuits have changed in register with motor behavior. In simple, undulatory fish, exemplified by the lamprey, two broad classes of interneurons shape motor neuron output: ipsilateral-projecting excitatory neurons, and commissural-projecting inhibitory neurons. An additional class of ipsilateral inhibitory neurons is required to generate escape swim behavior in larval zebrafish and tadpoles. In limbed vertebrates, a more complex spinal neuron composition is observed. In this review, we provide evidence that movement elaboration correlates with an increase and specialization of these three basic interneuron types into molecularly, anatomically, and functionally distinct subpopulations. We summarize recent work linking neuron types to movement-pattern generation across fish, amphibians, reptiles, birds and mammals.

【 授权许可】

Unknown   
Copyright © 2023 Wilson and Sweeney.

【 预 览 】
附件列表
Files Size Format View
RO202310106071486ZK.pdf 6510KB PDF download
  文献评价指标  
  下载次数:2次 浏览次数:0次