The Temporal Mechanisms Guiding Interneuron Differentiation in the Spinal Cord

International Journal of Molecular Sciences

Ying Zhang¹  Dylan Deska-Gauthier¹ 

[1] Brain Repair Center, Department of Neuroscience, Faculty of Medicine, Dalhousie University, Halifax, NS B3H 4R2, Canada;

关键词: spinal cord;    interneuron;    subpopulations;    neurogenesis;    mouse;    zebra fish;   

DOI  :  10.3390/ijms22158025

来源: DOAJ

【 摘 要 】

Neurogenesis timing is an essential developmental mechanism for neuronal diversity and organization throughout the central nervous system. In the mouse spinal cord, growing evidence is beginning to reveal that neurogenesis timing acts in tandem with spatial molecular controls to diversify molecularly and functionally distinct post-mitotic interneuron subpopulations. Particularly, in some cases, this temporal ordering of interneuron differentiation has been shown to instruct specific sensorimotor circuit wirings. In zebrafish, in vivo preparations have revealed that sequential neurogenesis waves of interneurons and motor neurons form speed-dependent locomotor circuits throughout the spinal cord and brainstem. In the present review, we discuss temporal principals of interneuron diversity taken from both mouse and zebrafish systems highlighting how each can lend illuminating insights to the other. Moving forward, it is important to combine the collective knowledge from different systems to eventually understand how temporally regulated subpopulation function differentially across speed- and/or state-dependent sensorimotor movement tasks.

【 授权许可】

Unknown