From lymphatic endothelial cell migration to formation of tubular lymphatic vascular network

Frontiers in Physiology

Physiology

Tomohiro Shiiya¹  Masanori Hirashima² 

[1] Division of Pharmacology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan;null;

关键词: cell adhesion;    cell polarization;    chemotactic factor;    lymphatic endothelial cell;    migration;   

DOI  :  10.3389/fphys.2023.1124696

 received in 2022-12-15, accepted in 2023-02-10,  发布年份 2023

来源: Frontiers

【 摘 要 】

During development, lymphatic endothelial cell (LEC) progenitors differentiate from venous endothelial cells only in limited regions of the body. Thus, LEC migration and subsequent tube formation are essential processes for the development of tubular lymphatic vascular network throughout the body. In this review, we discuss chemotactic factors, LEC-extracellular matrix interactions and planar cell polarity regulating LEC migration and formation of tubular lymphatic vessels. Insights into molecular mechanisms underlying these processes will help in understanding not only physiological lymphatic vascular development but lymphangiogenesis associated with pathological conditions such as tumors and inflammation.

【 授权许可】

Unknown   
Copyright © 2023 Shiiya and Hirashima.