Emerging Role of Sphingosine-1-phosphate in Inflammation, Cancer, and Lymphangiogenesis

Biomolecules

Wei-Ching Huang¹  Masayuki Nagahashi¹  Krista P. Terracina¹ 

[1] Division of Surgical Oncology, Department of Surgery, Virginia Commonwealth University School of Medicine and Massey Cancer Center, Richmond, VA 23298-0011, USA;

关键词: sphingolipids;    sphingosine-1-phosphate;    inflammation;    lymphangiogenesis;    cancer;    lymphatic endothelial cell;    VEGF;    angiopoietin;    spinster 2;    metastasis;   

DOI  :  10.3390/biom3030408

来源: mdpi

【 摘 要 】

The main function of the lymphatic system is to control and maintain fluid homeostasis, lipid transport, and immune cell trafficking. In recent years, the pathological roles of lymphangiogenesis, the generation of new lymphatic vessels from preexisting ones, in inflammatory diseases and cancer progression are beginning to be elucidated. Sphingosine-1-phosphate (S1P), a bioactive lipid, mediates multiple cellular events, such as cell proliferation, differentiation, and trafficking, and is now known as an important mediator of inflammation and cancer. In this review, we will discuss recent findings showing the emerging role of S1P in lymphangiogenesis, in inflammation, and in cancer.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.