Basophils in pruritic skin diseases

Frontiers in Immunology

Immunology

Daniela Wiebe¹  Maren M. Limberg¹  Natalie Gray²  Ulrike Raap³ 

[1] Division of Experimental Allergy and Immunodermatology, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany;Division of Experimental Allergy and Immunodermatology, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany;Division of Anatomy, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany;Division of Experimental Allergy and Immunodermatology, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany;Research Center for Neurosensory Science, Carl von Ossietzky University Oldenburg, Oldenburg, Germany;University Clinic of Dermatology and Allergy, University of Oldenburg, Oldenburg, Germany;

关键词: basophils;    IL-31;    atopic dermatitis;    neuro-immune interaction;    pruritus;   

DOI  :  10.3389/fimmu.2023.1213138

 received in 2023-04-27, accepted in 2023-06-14,  发布年份 2023

来源: Frontiers

【 摘 要 】

Basophils are rare cells in the peripheral blood which have the capability to infiltrate into the skin. Invasion of basophils has been detected in pruritic skin diseases, including atopic dermatitis, bullous pemphigoid, chronic spontaneous urticaria and contact dermatitis. In the skin, basophils are important players of the inflammatory immune response, as they release Th2 cytokines, including interleukin (IL)-4 and IL-13, subsequently inducing the early activation of T-cells. Further, basophils release a multitude of mediators, such as histamine and IL-31, which both play an important role in the initiation of the pruritic response via activation of sensory nerves. Chronic pruritus significantly affects the quality of life and the working capability of patients, though its mechanisms are not fully elucidated yet. Since basophils and neurons share many receptors and channels, bidirectional interaction mechanisms, which drive the sensation of itch, are highlighted in this review.

【 授权许可】

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Copyright © 2023 Wiebe, Limberg, Gray and Raap