Apigenin Inhibits IL-31 Cytokine in Human Mast Cell and Mouse Skin Tissues

Molecules

Hyeonhwa Oh¹  HyunJu Kang¹  DenisNchang Che²  SeonIl Jang²  ByoungOk Cho³  Young-Soo Kim³  Ji-Su Kim⁴  JaeYoung Shin⁴ 

[1] A Co., Ltd., Jeonju-si, Jeollabuk-do 54840, Korea;Department of Food Science and Technology, Chonbuk National University, Jeonju-si, Jeollabuk-do 54896, Korea;Department of Health Management, Jeonju University, Jeonju-si, Jeollabuk-do 55069, Korea;;Research Institute, Ato Q&

关键词: IL-31;    apigenin;    mast cells;    atopic dermatitis;    MAPK;    NF-κB;   

DOI  :  10.3390/molecules24071290

来源: DOAJ

【 摘 要 】

IL-31 is a recently discovered cytokine that is produced not only in T-cells but also in mast cells. It is strongly implicated to play a key role in inflammatory diseases and in the pathogenesis of itch in atopic dermatitis. Apigenin, a flavonoid of plant origin has numerous biological applications. In this study, we showed that apigenin modulates IL-31 mRNA, protein expression, and release in stimulated human mast (HMC-1) by inhibiting the phosphorylation activation of MAPK and NF-κB. To determine whether apigenin has similar effects in vivo, using Compound 48/80, we developed an atopic dermatitis itch model in mice and found an increase in IL-31 expression in the skin. We also revealed that apigenin prevents the infiltration and degranulation of mast cells and suppressed mRNA and protein expression of IL-31 in the skin of mice. These results provide a new suggestion of the potential applicability of apigenin for treatment of various inflammatory diseases and itch mediated by IL-31.

【 授权许可】

Unknown