Insights into vitamin A in bladder cancer, lack of attention to gut microbiota?

Frontiers in Immunology

Immunology

Liying Zheng¹  Biao Qian²  Junrong Zou²  Wei Li³  Jun Zou³  Tao Chen³  Qi Chen³  Peiyue Luo³ 

[1] Department of Graduate, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China;Department of Urology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China;Key Laboratory of Urology and Andrology of Ganzhou, Ganzhou, Jiangxi, China;The First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, China;Department of Urology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China;Key Laboratory of Urology and Andrology of Ganzhou, Ganzhou, Jiangxi, China;

关键词: vitamin A;    retinoic acid;    gut microbiota;    lipopolysaccharides;    bladder cancer;   

DOI  :  10.3389/fimmu.2023.1252616

 received in 2023-07-04, accepted in 2023-08-14,  发布年份 2023

来源: Frontiers

【 摘 要 】

Vitamin A has long been associated with bladder cancer, and many exogenous vitamin A supplements, vitamin A derivatives, and synthetic drugs have been investigated over the years. However, the effectiveness of these strategies in clinical practice has not met expectations, and they have not been widely adopted. Recent medical research on intestinal flora has revealed that bladder cancer patients exhibit reduced serum vitamin A levels and an imbalance of gut microbiota. In light of the close relationship between gut microbiota and vitamin A, one can speculate that a complex regulatory mechanism exists between the two in the development and occurrence of bladder cancer. As such, further exploration of their interaction in bladder cancer may help guide the use of vitamin A for preventive purposes. During the course of this review, attention is paid to the influence of intestinal microbiota on the vitamin A metabolism and the RA signaling pathway, as well as the mutual promotion relationships between them in the prevention of bladder cancer, In addition, it emphasizes the importance of intestinal microbiota for bladder cancer prevention and treatment.

【 授权许可】

Unknown   
Copyright © 2023 Luo, Zheng, Zou, Chen, Zou, Li, Chen and Qian