Photodecomposition and Phototoxicity of Natural Retinoids

International Journal of Environmental Research and Public Health

William H. Tolleson¹  Shui-Hui Cherng¹  Qingsu Xia¹  Mary Boudreau¹  Jun Jie Yin³  Wayne G. Wamer³  Paul C. Howard¹  Hongtao Yu² 

[1] National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA;Department of Chemistry, Jackson State University, Jackson, MS 39217, USA;Office of Cosmetics and Colors, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740, USA

关键词: Retinol;    vitamin A;    retinoic acid;    retinyl palmitate;    phototoxicity;    photocarcinogenicity;   

DOI  :  10.3390/ijerph2005010147

来源: mdpi

【 摘 要 】

Sunlight is a known human carcinogen. Many cosmetics contain retinoid-based compounds, such as retinyl palmitate (RP), either to protect the skin or to stimulate skin responses that will correct skin damaged by sunlight. However, little is known about the photodecomposition of some retinoids and the toxicity of these retinoids and their sunlight-induced photodecomposition products on skin. Thus, studies are required to test whether topical application of retinoids enhances the phototoxicity and photocarcinogenicity of sunlight and UV light. Mechanistic studies are needed to provide insight into the disposition of retinoids in vitro and on the skin, and to test thoroughly whether genotoxic damage by UV-induced radicals may participate in any toxicity of topically applied retinoids in the presence of UV light. This paper reports the update information and our experimental results on photostability, photoreactions, and phototoxicity of the natural retinoids including retinol (ROH), retinal, retinoid acid (RA), retinyl acetate, and RP (Figure 1).

【 授权许可】

CC BY   
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