A snap-shot of a diarrheal epidemic in Dhaka due to enterotoxigenic Escherichia coli and Vibrio cholerae O1 in 2022

Frontiers in Public Health

Public Health

Aninda Rahman¹  Md Nazmul Islam¹  Afroza Akter²  Ashraful Islam Khan²  Taufiqur Rahman Bhuiyan²  Md Golam Firoj²  Imam Tauheed²  Baharul Alam²  Tasnuva Ahmed²  Sadia Isfat Ara Rahman²  Mokibul Hassan Afrad²  Fahima Chowdhury²  Firdausi Qadri²  Faisal Ahmmed² 

[1] Directorate General of Health Services, Dhaka, Bangladesh;International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh;

关键词: ETEC;    cholera;    co-infection;    enterotoxin;    colonization factor;    seasonal peak;    Bangladesh;   

DOI  :  10.3389/fpubh.2023.1132927

 received in 2022-12-28, accepted in 2023-03-24,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundEnterotoxigenic Escherichia coli (ETEC) and Vibrio cholerae O1 are most common bacterial causes of diarrheal diseases in Bangladesh. This analysis projected distribution of ETEC and V. cholerae O1 among diarrheal patients of icddr,b, Dhaka hospital in two diarrheal peaks of 2022.MethodologyUnder the 2% systematic surveillance system, stool samples collected from diarrheal patients of icddr,b hospital were cultured and diagnostic testing was done for ETEC and V. cholerae O1. Comparison of positive cases was done between first peak (March–April) and second peak (October–November) in 2022.ResultsA total of 2,937 stool specimens were tested of which 12% were ETEC and 20% were V. cholerae O1. About 40% of the severe dehydration cases were infected with V. cholerae O1. Predominant ETEC enterotoxin type was ‘LT/ST’ (41%). The LT enterotoxin significantly increased from 13% to 28% in the second peak (p = 0.015). The predominant colonization factors (CFs) on ETEC were CS5 + CS6 (23%), followed by CS6 (15%). CF-positive isolates was significantly higher in the second peak (36%) than in the first peak (22%) (p = 0.043). Total 14% cases were co-infected with ETEC and V. cholerae O1. Significant differences in the distribution of enterotoxin types were observed (p = 0.029) among the co-infection cases.ConclusionChanging patterns of enterotoxin and CFs observed in ETEC pathogens should be taken into consideration for ETEC vaccine development. Considering cholera and ETEC biannual trends in causing diarrheal epidemics and outbreaks, emphasizes the need for thoughts on combination vaccine strategies for preventing acute watery diarrhea due to the two major bacterial pathogens.

【 授权许可】

Unknown   
Copyright © 2023 Tauheed, Ahmed, Akter, Firoj, Ahmmed, Rahman, Afrad, Islam, Rahman, Khan, Alam, Bhuiyan, Chowdhury and Qadri.