NUDT21 Promotes Tumor Growth and Metastasis Through Modulating SGPP2 in Human Gastric Cancer

Frontiers in Oncology

Oncology

Ying Zhang¹  Rumeng Zhang²  Xiao Cheng²  Lin Li²  Keshuo Ding³  Zhengsheng Wu³  Yong Zhu⁴ 

[1] Department of Oncology of the First Affiliated Hospital, Division of Life Science and Medicine, The CAS Key Laboratory of Innate Immunity and Chronic Disease, University of Science and Technology of China, Hefei, China;Department of Pathology, School of Basic Medicine, Anhui Medical University, Hefei, China;Department of Pathology, School of Basic Medicine, Anhui Medical University, Hefei, China;Department of Pathology, The First Affiliated Hospital of Anhui Medical University, Hefei, China;Department of Pathophysiology, School of Basic Medicine, Anhui Medical University, Hefei, China;

关键词: NUDT21;    SGPP2;    gastric cancer;    proliferation;    metastasis;   

DOI  :  10.3389/fonc.2021.670353

 received in 2021-02-21, accepted in 2021-09-13,  发布年份 2021

来源: Frontiers

【 摘 要 】

Gastric cancer is one of the major malignancies with poor survival outcome. In this study, we reported that NUDT21 promoted cell proliferation, colony formation, cell migration and invasion in gastric cancer cells. The expression levels of NUDT21 were found to be much higher in human gastric cancer tissues compared with normal gastric tissues. NUDT21 expression was positively correlated with tumor size, lymph node metastasis and clinical stage in gastric cancer patients. High level of NUDT21 was associated with poor overall survival (OS) rates in gastric cancer patients. The expression levels of NUDT21 were also much higher in gastric cancer tissues from patients with distant metastasis compared with those of patients without distant metastasis. Moreover, forced expression of NUDT21 in gastric cancer cells promoted tumor growth and cell proliferation in xenograft nude mice, and depletion of NUDT21 in gastric cancer cells restrained lung metastasis in vivo. Through high throughput RNA-sequencing, SGPP2 was identified to be positively regulated by NUDT21 and mediated the tumor promoting role of NUDT21 in gastric cancer cells. Therefore, NUDT21 played an oncogenic role in human gastric cancer cells. NUDT21 could be considered as a novel potential target for gastric cancer therapy.

【 授权许可】

Unknown   
Copyright © 2021 Zhu, Zhang, Zhang, Cheng, Li, Wu and Ding