New insights into autophagy in inflammatory subtypes of asthma

Frontiers in Immunology

Immunology

Wei Yang¹  Wei Li²  Hongna Dong²  Simin Zhu²  Peng Gao²  Yuqiu Hao²  Ling Zhu² 

[1] Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun, China;Department of Respiratory Medicine, The Second Hospital of Jilin University, Changchun, Jilin, China;

关键词: asthma;    autophagy;    biomarker;    therapeutic target;    inflammation;   

DOI  :  10.3389/fimmu.2023.1156086

 received in 2023-02-01, accepted in 2023-03-27,  发布年份 2023

来源: Frontiers

【 摘 要 】

Asthma is a heterogeneous airway disease characterized by airway inflammation and hyperresponsiveness. Autophagy is a self-degrading process that helps maintain cellular homeostasis. Dysregulation of autophagy is involved in the pathogenesis of many diseases. In the context of asthma, autophagy has been shown to be associated with inflammation, airway remodeling, and responsiveness to drug therapy. In-depth characterization of the role of autophagy in asthma can enhance the understanding of the pathogenesis, and provide a theoretical basis for the development of new biomarkers and targeted therapy for asthma. In this article, we focus on the relationship of autophagy and asthma, and discuss its implications for asthma pathogenesis and treatment.

【 授权许可】

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Copyright © 2023 Dong, Yang, Li, Zhu, Zhu, Gao and Hao