Advantages of Widefield Optical Coherence Tomography in the Diagnosis of Retinopathy of Prematurity

Frontiers in Pediatrics

Pediatrics

Susan Ostmo¹  J. Peter Campbell¹  Thanh-Tin P. Nguyen¹  Yifan Jian²  Yali Jia²  David Huang²  Xiang Wei²  Shuibin Ni²  Shanjida Khan²  Michael F. Chiang³ 

[1] School of Medicine, Casey Eye Institute, Oregon Health and Science University, Portland, OR, United States;School of Medicine, Casey Eye Institute, Oregon Health and Science University, Portland, OR, United States;Department of Biomedical Engineering, Casey Eye Institute, Oregon Health and Science University, Portland, OR, United States;School of Medicine, Casey Eye Institute, Oregon Health and Science University, Portland, OR, United States;National Eye Institute, National Institutes of Health, Bethesda, MD, United States;

关键词: retinopathy of prematurity;    pediatric retina;    optical coherence tomography;    handheld optical coherence tomography;    optical coherence tomography with angiography;   

DOI  :  10.3389/fped.2021.797684

 received in 2021-10-19, accepted in 2021-12-21,  发布年份 2022

来源: Frontiers

【 摘 要 】

Recent advances in portable optical coherence tomography (OCT) and OCT angiography (OCTA) have resulted in wider fields of view (FOV) and shorter capture times, further expanding the potential clinical role of OCT technology in the diagnosis and management of retinopathy of prematurity (ROP). Using a prototype, handheld OCT device, retinal imaging was obtained in non-sedated infants in the neonatal intensive care unit (NICU) as well as sedated infants in the operating room of Oregon Health & Science University (OHSU) Hospital. In this observational study, we provide an overview of potential advantages of OCT-based disease assessment in ROP. We observed that next-generation OCT imaging (a) may be sufficient for objective diagnosis and zone/stage/plus disease categorization, (b) allows for minimally-invasive longitudinal monitoring of disease progression and post-treatment course, (c) provides three-dimensional mapping of the vitreoretinal interface, and (d) with OCTA, enables dye-free visualization of normal and pathologic vascular development.

【 授权许可】

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Copyright © 2022 Nguyen, Ni, Khan, Wei, Ostmo, Chiang, Jia, Huang, Jian and Campbell.