Frontiers in Immunology | |
Revisiting Aire and tissue-restricted antigens at single-cell resolution | |
Immunology | |
Takeshi Oya1  Minoru Matsumoto2  Koichi Tsuneyama3  Mitsuru Matsumoto4  Hideyuki Yoshida5  | |
[1] Department of Molecular Pathology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan;Department of Molecular Pathology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan;Division of Molecular Immunology, Institute for Enzyme Research, Tokushima University, Tokushima, Japan;Department of Pathology and Laboratory Medicine, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan;Division of Molecular Immunology, Institute for Enzyme Research, Tokushima University, Tokushima, Japan;YCI Laboratory for Immunological Transcriptomics, RIKEN Center for Integrative Medical Science, Yokohama, Japan; | |
关键词: mTEC; Aire; single-cell analysis; heterogeneity; tissue-restricted antigens; | |
DOI : 10.3389/fimmu.2023.1176450 | |
received in 2023-02-28, accepted in 2023-04-20, 发布年份 2023 | |
来源: Frontiers | |
【 摘 要 】
The thymus is a highly specialized organ that plays an indispensable role in the establishment of self-tolerance, a process characterized by the “education” of developing T-cells. To provide competent T-cells tolerant to self-antigens, medullary thymic epithelial cells (mTECs) orchestrate negative selection by ectopically expressing a wide range of genes, including various tissue-restricted antigens (TRAs). Notably, recent advancements in the high-throughput single-cell analysis have revealed remarkable heterogeneity in mTECs, giving us important clues for dissecting the mechanisms underlying TRA expression. We overview how recent single-cell studies have furthered our understanding of mTECs, with a focus on the role of Aire in inducing mTEC heterogeneity to encompass TRAs.
【 授权许可】
Unknown
Copyright © 2023 Matsumoto, Yoshida, Tsuneyama, Oya and Matsumoto
【 预 览 】
Files | Size | Format | View |
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RO202310105641803ZK.pdf | 1794KB | download |