Revisiting Aire and tissue-restricted antigens at single-cell resolution

Frontiers in Immunology

Immunology

Takeshi Oya¹  Minoru Matsumoto²  Koichi Tsuneyama³  Mitsuru Matsumoto⁴  Hideyuki Yoshida⁵ 

[1] Department of Molecular Pathology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan;Department of Molecular Pathology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan;Division of Molecular Immunology, Institute for Enzyme Research, Tokushima University, Tokushima, Japan;Department of Pathology and Laboratory Medicine, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan;Division of Molecular Immunology, Institute for Enzyme Research, Tokushima University, Tokushima, Japan;YCI Laboratory for Immunological Transcriptomics, RIKEN Center for Integrative Medical Science, Yokohama, Japan;

关键词: mTEC;    Aire;    single-cell analysis;    heterogeneity;    tissue-restricted antigens;   

DOI  :  10.3389/fimmu.2023.1176450

 received in 2023-02-28, accepted in 2023-04-20,  发布年份 2023

来源: Frontiers

【 摘 要 】

The thymus is a highly specialized organ that plays an indispensable role in the establishment of self-tolerance, a process characterized by the “education” of developing T-cells. To provide competent T-cells tolerant to self-antigens, medullary thymic epithelial cells (mTECs) orchestrate negative selection by ectopically expressing a wide range of genes, including various tissue-restricted antigens (TRAs). Notably, recent advancements in the high-throughput single-cell analysis have revealed remarkable heterogeneity in mTECs, giving us important clues for dissecting the mechanisms underlying TRA expression. We overview how recent single-cell studies have furthered our understanding of mTECs, with a focus on the role of Aire in inducing mTEC heterogeneity to encompass TRAs.

【 授权许可】

Unknown   
Copyright © 2023 Matsumoto, Yoshida, Tsuneyama, Oya and Matsumoto