International Journal of Molecular Sciences | |
Aire-Overexpressing Dendritic Cells Induce Peripheral CD4+ T Cell Tolerance | |
Dongbei Li1  Haijun Li1  Haiying Fu2  Kunwei Niu2  Yantong Guo2  Chuan Guo2  Jitong Sun2  Yi Li1  Wei Yang1  | |
[1] Department of Immunology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, China | |
关键词: Aire; DCs; CD4+T cells; T1D; | |
DOI : 10.3390/ijms17010038 | |
来源: mdpi | |
【 摘 要 】
Autoimmune regulator (Aire) can promote the ectopic expression of peripheral tissue-restricted antigens (TRAs) in thymic medullary epithelial cells (mTECs), which leads to the deletion of autoreactive T cells and consequently prevents autoimmune diseases. However, the functions of Aire in the periphery, such as in dendritic cells (DCs), remain unclear. This study’s aim was to investigate the effect of Aire-overexpressing DCs (Aire cells) on the functions of CD4+ T cells and the treatment of type 1 diabetes (T1D). We demonstrated that Aire cells upregulated the mRNA levels of the tolerance-related molecules
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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