Recent Advances in Chinese Herbal Medicine for Cerebral Ischemic Reperfusion Injury

Frontiers in Pharmacology

Pharmacology

Chongyu Shao¹  Chang Li¹  Haitong Wan¹  Ling Zhang¹  Yu He²  Ping Huang² 

[1] School of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, China;School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, China;

关键词: Chinese herbal medicine;    cerebral ischemia;    reperfusion injury;    pathophysiology;    pharmacological effects;    mechanisms;   

DOI  :  10.3389/fphar.2021.688596

 received in 2021-03-31, accepted in 2021-11-29,  发布年份 2022

来源: Frontiers

【 摘 要 】

Cerebral ischemic reperfusion injury (CI/RI) is a critical factor that leads to a poor prognosis in patients with ischemic stroke. It is an extremely complicated pathological process that is clinically characterized by high rates of disability and mortality. Current available treatments for CI/RI, including mechanical and drug therapies, are often accompanied by significant side effects. Therefore, it is necessary to discovery new strategies for treating CI/RI. Many studies confirm that Chinese herbal medicine (CHM) was used as a potential drug for treatment of CI/RI with the advantages of abundant resources, good efficacy, and few side effects. In this paper, we investigate the latest drug discoveries and advancements on CI/RI, make an overview of relevant CHM, and systematically summarize the pathophysiology of CI/RI. In addition, the protective effect and mechanism of related CHM, which includes extraction of single CHM and CHM formulation and preparation, are discussed. Moreover, an outline of the limitations of CHM and the challenges we faced are also presented. This review will be helpful for researchers further propelling the advancement of drugs and supplying more knowledge to support the application of previous discoveries in clinical drug applications against CI/RI.

【 授权许可】

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Copyright © 2022 Huang, Wan, Shao, Li, Zhang and He.