RNA-binding proteins as a common ground for neurodegeneration and inflammation in amyotrophic lateral sclerosis and multiple sclerosis

Frontiers in Molecular Neuroscience

Molecular Neuroscience

Jose de Jesus Aceves-Buendia¹  Erwin Chiquete¹  Ricardo Hernández-Martínez²  Isabel Acosta-Galeana³  Tania Reyes-Cruz⁴ 

[1] Departamento de Neurología y Psiquiatría, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico;Facultad de Ciencias Químicas, Universidad Veracruzana, Xalapa, Mexico;Facultad de Química, Universidad Nacional Autónoma de México, Mexico City, Mexico;Laboratorio de Biología Molecular, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana, Mexico City, Mexico;

关键词: TDP-43;    ALS;    MS;    neurodegeneration;    DNA-binding proteins;    RNA-binding proteins;    autoimmunity;   

DOI  :  10.3389/fnmol.2023.1193636

 received in 2023-03-25, accepted in 2023-06-14,  发布年份 2023

来源: Frontiers

【 摘 要 】

The neurodegenerative and inflammatory illnesses of amyotrophic lateral sclerosis and multiple sclerosis were once thought to be completely distinct entities that did not share any remarkable features, but new research is beginning to reveal more information about their similarities and differences. Here, we review some of the pathophysiological features of both diseases and their experimental models: RNA-binding proteins, energy balance, protein transportation, and protein degradation at the molecular level. We make a thorough analysis on TDP-43 and hnRNP A1 dysfunction, as a possible common ground in both pathologies, establishing a potential link between neurodegeneration and pathological immunity. Furthermore, we highlight the putative variations that diverge from a common ground in an atemporal course that proposes three phases for all relevant molecular events.

【 授权许可】

Unknown   
Copyright © 2023 Acosta-Galeana, Hernández-Martínez, Reyes-Cruz, Chiquete and Aceves-Buendia.