Traditional Chinese Manual Therapy (Tuina) reshape the function of default mode network in patients with lumbar disc herniation

Frontiers in Neuroscience

Neuroscience

Jie Li¹  Mao-Sheng Xu²  Ning Kong²  Dong-Ya Ling²  Wei Wang²  Chen Liu³  Xin Jin³  Jin-Er Chai³  Xiao-Lei Zhao³  Hong-Gen Du³  Zhong Jiang³  Shao Chen³  Xiao-Min Chen³  Qin Huang³  Ya Wen³ 

[1] Department of Radiology, Changshu No.2 People’s Hospital, The Affiliated Changshu Hospital of Xuzhou Medical University, Changshu, Jiangsu, China;Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China;Department of Tuina, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China;

关键词: lumbar disc herniation;    resting-state fMRI;    regional homogeneity;    functional connectivity;    Tuina;   

DOI  :  10.3389/fnins.2023.1125677

 received in 2022-12-16, accepted in 2023-02-24,  发布年份 2023

来源: Frontiers

【 摘 要 】

PurposeInvestigating the changes of regional homogeneity (ReHo) values and both static and dynamic functional connectivity (FC) before and after Traditional Chinese Manual Therapy (Tuina) in patients with lumbar disk herniation (LDH) through resting-state functional magnetic resonance imaging (RS-fMRI). Based on this, we observe the effect of Tuina on the above abnormal changes.MethodsPatients with LDH (n = 27) and healthy controls (HCs) (n = 28) were recruited. The functional magnetic resonance imaging (fMRI) scanning was performed two times in LDH patients, before Tuina (time point 1, LDH-pre) and after the sixth Tuina (time point 2, LDH-pos). And for one time in HCs which received no intervention. The ReHo values were compared between LDH-pre and HCs. The significant clusters detected by ReHo analysis were selected as seeds to calculate static functional connectivity (sFC). We also applied the sliding-window to perform dynamic functional connectivity (dFC). To evaluate the Tuina effect, the mean ReHo and FC values (both static and dynamic) were extracted from significant clusters and compared between LDH and HCs.ResultsIn comparison to HCs, LDH patients displayed decreased ReHo in the left orbital part middle frontal gyrus (LO-MFG). For sFC analysis, no significant difference was found. However, we found decreased dFC variance between LO-MFG and the left Fusiform, and increased dFC variance in the left orbital inferior frontal gyrus and left precuneus. Both ReHo and dFC values revealed after Tuina, the brain activities in LDH patients were similar to HCs.ConclusionThe present study characterized the altered patterns of regional homogeneity in spontaneous brain activity and those of functional connectivity in patients with LDH. Tuina can reshape the function of the default mode network (DMN) in LDH patients, which may contribute to the analgesic effect of Tuina in LDH patients.

【 授权许可】

Unknown   
Copyright © 2023 Chen, Wen, Chen, Jin, Liu, Wang, Kong, Ling, Huang, Chai, Zhao, Li, Xu, Jiang and Du.