Diabetic endothelial microangiopathy and pulmonary dysfunction

Frontiers in Endocrinology

Endocrinology

Xin Zhang¹  Yingying Xie²  Yan Mo³  Chuntao Liu⁴  Faming Jiang⁴  Lanlan Zhang⁴ 

[1] Department of Gastroenterology, West China Hospital of Sichuan University, Chengdu, China;Department of Nephrology, Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China;Department of Neurology Medicine, The Aviation Industry Corporation of China (AVIC) 363 Hospital, Chengdu, China;Department of Respiratory and Critical Care Medicine, Division of Pulmonary Diseases, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, China;

关键词: endothelial cells;    COVID-19;    asthma;    COPD;    type-2 diabetes;   

DOI  :  10.3389/fendo.2023.1073878

 received in 2022-10-19, accepted in 2023-02-17,  发布年份 2023

来源: Frontiers

【 摘 要 】

Type 2 diabetes mellitus (T2DM) is a widespread metabolic condition with a high global morbidity and mortality rate that affects the whole body. Their primary consequences are mostly caused by the macrovascular and microvascular bed degradation brought on by metabolic, hemodynamic, and inflammatory variables. However, research in recent years has expanded the target organ in T2DM to include the lung. Inflammatory lung diseases also impose a severe financial burden on global healthcare. T2DM has long been recognized as a significant comorbidity that influences the course of various respiratory disorders and their disease progress. The pathogenesis of the glycemic metabolic problem and endothelial microangiopathy of the respiratory disorders have garnered more attention lately, indicating that the two ailments have a shared history. This review aims to outline the connection between T2DM related endothelial cell dysfunction and concomitant respiratory diseases, including Coronavirus disease 2019 (COVID-19), asthma, chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF).

【 授权许可】

Unknown   
Copyright © 2023 Zhang, Jiang, Xie, Mo, Zhang and Liu