Histone 4 lysine 20 tri-methylation: a key epigenetic regulator in chromatin structure and disease

Frontiers in Genetics

Genetics

Andrea L. Kasinski¹  Alejandra Agredo² 

[1] Department of Biological Sciences, Purdue University, West Lafayette, IN, United States;Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN, United States;Department of Biological Sciences, Purdue University, West Lafayette, IN, United States;Purdue Life Sciences Interdisciplinary Program (PULSe), Purdue University, West Lafayette, IN, United States;

关键词: H4K20me3;    chromatin;    heterochromatin;    histone;    methylation;    disease;    cancer;    homeostasis;   

DOI  :  10.3389/fgene.2023.1243395

 received in 2023-06-20, accepted in 2023-08-07,  发布年份 2023

来源: Frontiers

【 摘 要 】

Chromatin is a vital and dynamic structure that is carefully regulated to maintain proper cell homeostasis. A great deal of this regulation is dependent on histone proteins which have the ability to be dynamically modified on their tails via various post-translational modifications (PTMs). While multiple histone PTMs are studied and often work in concert to facilitate gene expression, here we focus on the tri-methylation of histone H4 on lysine 20 (H4K20me3) and its function in chromatin structure, cell cycle, DNA repair, and development. The recent studies evaluated in this review have shed light on how H4K20me3 is established and regulated by various interacting partners and how H4K20me3 and the proteins that interact with this PTM are involved in various diseases. Through analyzing the current literature on H4K20me3 function and regulation, we aim to summarize this knowledge and highlights gaps that remain in the field.

【 授权许可】

Unknown   
Copyright © 2023 Agredo and Kasinski.