Effect of viscous soluble dietary fiber on glucose and lipid metabolism in patients with type 2 diabetes mellitus: a systematic review and meta-analysis on randomized clinical trials

Frontiers in Nutrition

Nutrition

Shaokang Wang¹  Hui Xia¹  Tingqing Yu¹  Xinyi Cao¹  Guiju Sun¹  Wang Liao¹  Kun Lu¹  Liang Chen² 

[1] Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, China;Public Service Platform of South China Sea for R&D Marine Biomedicine Resources, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, Guangdong, China;

关键词: viscous soluble dietary fiber;    glucose and lipid metabolism;    blood glucose;    blood lipid;    RCTs;    meta-analysis;   

DOI  :  10.3389/fnut.2023.1253312

 received in 2023-07-05, accepted in 2023-08-08,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundThe effect of viscous soluble dietary fiber on glucose and lipid metabolism in type 2 diabetes mellitus (T2DM) remains controversial, and the dose–response relationship of its effect on blood glucose and blood lipid level is still unclear.MethodsWe conducted comprehensive searches in several databases up to 17 January 2023. We conducted a dose–response analysis of randomized controlled trials (RCTs) to investigate the effect of viscous dietary fiber on glucose and lipid metabolism in patients with T2DM.ResultsStatistical significance was observed in the decreases of glycosylated hemoglobin (HbA1c) (mean difference) [MD = −0.47; 95%CI: (−0.66, −0.27)], fasting blood glucose (FBG) [MD = −0.93; 95%CI: (−1.46, −0.41)], total cholesterol (TC) [MD = −0.33; 95%CI: (−0.46, −0.21)], and low-density lipoprotein and cholesterol (LDL-C) [MD = −0.24; 95%CI: (−0.35, −0.13)]. Contrarily, no difference was observed regarding the level of high-density lipoprotein cholesterol (HDL-C) or triglyceride (TG). In addition, the effect on fasting insulin remains unclear. Results from the subgroup analyses showed that an intervention duration longer than 6 weeks had a significant effect on the HbA1c level; a treatment dosage higher than 8.3 g/day had a significant effect on the FBG level.ConclusionsSupplementation of viscous dietary fiber is beneficial to control blood glucose and blood lipid in T2DM.

【 授权许可】

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Copyright © 2023 Lu, Yu, Cao, Xia, Wang, Sun, Chen and Liao.