Long noncoding RNAs in cardiometabolic disorders

FEBS Letters

article

Rio P. Juni¹  Kelly C. 't Hart¹  Riekelt H. Houtkooper³  Reinier A. Boon¹ 

[1] Department of Physiology, Amsterdam UMC location Vrije Universiteit Amsterdam;Department of Microcirculation, Amsterdam Cardiovascular Sciences;Laboratory Genetic Metabolic Diseases, Amsterdam UMC location University of Amsterdam;Amsterdam Gastroenterology, Endocrinology, and Metabolism Institute, Amsterdam UMC location University of Amsterdam;Department of Diabetes & Metabolism, Amsterdam Cardiovascular Sciences;German Centre for Cardiovascular Research DZHK;Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University

关键词: aging;    cardiovascular system;    glucose and lipid metabolism;    LncRNA;    mitochondria;   

DOI  :  10.1002/1873-3468.14370

来源: John Wiley & Sons Ltd.

【 摘 要 】

The advancement of medical technology has led not only to an increase in life expectancy but also to a rise in aging-related diseases. Aging promotes metabolic disorders, in turn affecting cardiovascular health. Derailment of biological processes in the pancreas, liver, adipose tissue, and skeletal muscle impairs glucose and lipid metabolism, and mitochondrial function, triggering the development of diabetes and lipid-related disorders that inflict damage on cardiac and vascular tissues. Long noncoding RNAs (lncRNAs) regulate a wide range of biological process and are one of the key factors controlling metabolism and mitochondria. Here, we discuss the versatile function of lncRNAs involved in the metabolic regulation of glucose and lipid, and mitochondrial function, and how the dysregulation of lncRNAs induces the development of various metabolic disorders and their cardiovascular consequences.

【 授权许可】

Unknown