The influence of the ultrasonic treatment of working fluids on electrospun amorphous solid dispersions

Frontiers in Molecular Biosciences

Molecular Biosciences

Haisong Yang¹  Xuhua Lu¹  Haibin Wang¹  Yingying Lu²  Deng-Guang Yu³ 

[1] Department of Orthopaedics, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China;Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China;School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai, China;

关键词: blending electrospinning;    nanocomposites;    ultrasonic treatments;    working fluids;    amorphous solid dispersions;   

DOI  :  10.3389/fmolb.2023.1184767

 received in 2023-03-13, accepted in 2023-05-02,  发布年份 2023

来源: Frontiers

【 摘 要 】

Based on a working fluid consisting of a poorly water-soluble drug and a pharmaceutical polymer in an organic solvent, electrospinning has been widely exploited to create a variety of amorphous solid dispersions However, there have been very few reports about how to prepare the working fluid in a reasonable manner. In this study, an investigation was conducted to determine the influences of ultrasonic fluid pretreatment on the quality of resultant ASDs fabricated from the working fluids. SEM results demonstrated that nanofiber-based amorphous solid dispersions from the treated fluids treated amorphous solid dispersions exhibited better quality than the traditional nanofibers from untreated fluids in the following aspects: 1) a straighter linear morphology; 2) a smooth surface; and 3) a more evener diameter distribution. The fabrication mechanism associated with the influences of ultrasonic treatments of working fluids on the resultant nanofibers’ quality is suggested. Although XRD and ATR–FTIR experiments clearly verified that the drug ketoprofen was homogeneously distributed all over the TASDs and the traditional nanofibers in an amorphous state regardless of the ultrasonic treatments, the in vitro dissolution tests clearly demonstrated that the TASDs had a better sustained drug release performance than the traditional nanofibers in terms of the initial release rate and the sustained release time periods.

【 授权许可】

Unknown   
Copyright © 2023 Wang, Lu, Yang, Yu and Lu.