The potential role of T-cell metabolism-related molecules in chronic neuropathic pain after nerve injury: a narrative review

Frontiers in Immunology

Immunology

Maosha Dai¹  Xiaoke Dou¹  Junhao Long¹  Rui Chen¹  Juexi Yang¹  Yun Lin¹  Shujun Sun² 

[1] Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;Department of Pain, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;

关键词: chronic neuropathic pain;    T cell;    energy metabolism;    P2X7R;    PKM2;    adiponectin;   

DOI  :  10.3389/fimmu.2023.1107298

 received in 2022-11-24, accepted in 2023-04-27,  发布年份 2023

来源: Frontiers

【 摘 要 】

Neuropathic pain is a common type of chronic pain, primarily caused by peripheral nerve injury. Different T-cell subtypes play various roles in neuropathic pain caused by peripheral nerve damage. Peripheral nerve damage can lead to co-infiltration of neurons and other inflammatory cells, thereby altering the cellular microenvironment and affecting cellular metabolism. By elaborating on the above, we first relate chronic pain to T-cell energy metabolism. Then we summarize the molecules that have affected T-cell energy metabolism in the past five years and divide them into two categories. The first category could play a role in neuropathic pain, and we explain their roles in T-cell function and chronic pain, respectively. The second category has not yet been involved in neuropathic pain, and we focus on how they affect T-cell function by influencing T-cell metabolism. By discussing the above content, this review provides a reference for studying the direct relationship between chronic pain and T-cell metabolism and searching for potential therapeutic targets for the treatment of chronic pain on the level of T-cell energy metabolism.

【 授权许可】

Unknown   
Copyright © 2023 Dou, Chen, Yang, Dai, Long, Sun and Lin