JunB: a paradigm for Jun family in immune response and cancer

Frontiers in Cellular and Infection Microbiology

Cellular and Infection Microbiology

Xiao-yu Cai¹  Fu-jia Ren²  Guo-ying Fang²  Yao Yao³ 

[1] Department of Clinical Pharmacology, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, China;Department of Pharmacy, Hangzhou Women’s Hospital, Hangzhou, Zhejiang, China;Department of Pharmacy, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, China;

关键词: AP-1;    JunB;    immune response;    tumorigenesis;    tumor microenvironment;   

DOI  :  10.3389/fcimb.2023.1222265

 received in 2023-05-17, accepted in 2023-08-21,  发布年份 2023

来源: Frontiers

【 摘 要 】

Jun B proto-oncogene (JunB) is a crucial member of dimeric activator protein-1 (AP-1) complex, which plays a significant role in various physiological processes, such as placental formation, cardiovascular development, myelopoiesis, angiogenesis, endochondral ossification and epidermis tissue homeostasis. Additionally, it has been reported that JunB has great regulatory functions in innate and adaptive immune responses by regulating the differentiation and cytokine secretion of immune cells including T cells, dendritic cells and macrophages, while also facilitating the effector of neutrophils and natural killer cells. Furthermore, a growing body of studies have shown that JunB is involved in tumorigenesis through regulating cell proliferation, differentiation, senescence and metastasis, particularly affecting the tumor microenvironment through transcriptional promotion or suppression of oncogenes in tumor cells or immune cells. This review summarizes the physiological function of JunB, its immune regulatory function, and its contribution to tumorigenesis, especially focusing on its regulatory mechanisms within tumor-associated immune processes.

【 授权许可】

Unknown   
Copyright © 2023 Ren, Cai, Yao and Fang