The Biological Functions and Regulatory Mechanisms of Fatty Acid Binding Protein 5 in Various Diseases

Frontiers in Cell and Developmental Biology

Karl Nelson S. Marquez¹  Yu Zhan²  Yingying Shen²  Yong Guo²  Binyue Xu²  Jianzhong Gu²  Tian Xie³  Hao Zhang³  Lu Chen³  Ying He³  Xudong Chen³  Gongxing Chen³  Shuiping Liu³  Lvjia Zhuo³  Jinyu Zhu³  Shasha Qi³ 

[1] Clinical Medicine, Tongji Medical College, Huazhong University of Science and Technology, Hankou, China;Department of Oncology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China;Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, China;School of Pharmacy, Hangzhou Normal University, Hangzhou, China;

关键词: FABP5;    lipid metabolism;    lipid homeostasis;    cell differentiation;    immune response;    tumorigenesis;   

DOI  :  10.3389/fcell.2022.857919

来源: DOAJ

【 摘 要 】

In recent years, fatty acid binding protein 5 (FABP5), also known as fatty acid transporter, has been widely researched with the help of modern genetic technology. Emerging evidence suggests its critical role in regulating lipid transport, homeostasis, and metabolism. Its involvement in the pathogenesis of various diseases such as metabolic syndrome, skin diseases, cancer, and neurological diseases is the key to understanding the true nature of the protein. This makes FABP5 be a promising component for numerous clinical applications. This review has summarized the most recent advances in the research of FABP5 in modulating cellular processes, providing an in-depth analysis of the protein’s biological properties, biological functions, and mechanisms involved in various diseases. In addition, we have discussed the possibility of using FABP5 as a new diagnostic biomarker and therapeutic target for human diseases, shedding light on challenges facing future research.

【 授权许可】

Unknown