Integrative analysis of lysine acetylation-related genes and identification of a novel prognostic model for oral squamous cell carcinoma

Frontiers in Molecular Biosciences

Molecular Biosciences

Jiezhang Tang¹  Shi-Zhou Deng²  Lin Dai³  Bo Cheng⁴  Xuechen Wu⁴ 

[1]Department of Burn and Plastic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an, China

[2]Department of Hepatobiliary Surgery, Xi-Jing Hospital, The Fourth Military Medical University, Xi’an, China

[3]Department of Stomatology, The First Hospital of Wuhan, Wuhan, China

[4]Department of Stomatology, Zhongnan Hospital of Wuhan University, Wuhan, China

关键词: OSCC;    oral squamous cell carcinoma;    lysine acetylation;    prognostic model;    TCGA;    GEO;   

DOI  :  10.3389/fmolb.2023.1185832

 received in 2023-03-28, accepted in 2023-08-17,  发布年份 2023

来源: Frontiers

【 摘 要 】

Introduction: Oral squamous cell carcinoma (OSCC), which accounts for a high proportion of oral cancers, is characterized by high aggressiveness and rising incidence. Lysine acetylation is associated with cancer pathogenesis. Lysine acetylation-related genes (LARGs) are therapeutic targets and potential prognostic indicators in various tumors, including oral squamous cell carcinoma. However, systematic bioinformatics analysis of the Lysine acetylation-related genes in Oral squamous cell carcinoma is still unexplored.Methods: We analyzed the expression of 33 Lysine acetylation-related genes in oral squamous cell carcinoma and the effects of their somatic mutations on oral squamous cell carcinoma prognosis. Consistent clustering analysis identified two lysine acetylation patterns and the differences between the two patterns were further evaluated. Least absolute shrinkage and selection operator (LASSO) regression analysis was used to develop a lysine acetylation-related prognostic model using TCGA oral squamous cell carcinoma datasets, which was then validated using gene expression omnibus (GEO) dataset GSE41613.Results: Patients with lower risk scores had better prognoses, in both the overall cohort and within the subgroups These patients also had “hot” immune microenvironments and were more sensitive to immunotherapy.Disscussion: Our findings offer a new model for classifying oral squamous cell carcinoma and determining its prognosis and offer novel insights into oral squamous cell carcinoma diagnosis and treatment.

【 授权许可】

Unknown   
Copyright © 2023 Deng, Wu, Tang, Dai and Cheng.