The versatile hippo pathway in oral-maxillofacial development and bone remodeling

Developmental biology

Hui Yu^1¹  Xinyuan Zhang^1,2²  Lin Xiang^1,2³ 

[1]Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu, China^2

[2]Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China^3

[3]State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China^1

关键词: BMP;    bone morphogenetic protein;    CTGF;    connective tissue growth factor;    ECM;    extracellular matrix;    EMT;    epithelial-mesenchymal transformation;    Glut1;    glucose transporter 1;    GPCR;    G protein-coupled receptor;    KS;    Kaposi';    s sarcoma;    LATS;    large tumor suppressor kinase;    MST;    mammalian Sterile 20-like protein kinase;    OCN;    osteocalcin;    OSCC;    oral squamous cell carcinoma;    OSX;    Osterix;    PAR;    protease-activated receptor;    RUNX;    Runt-related transcription factor;    SAV;    Salvador;    Scrib;    Scribble;    SHH;    sonic hedgehog;    SS;    Sjogren';    s syndrome;    SSCs;    skeletal stem/stromal cells;    TAZ;    transcriptional coactivator with a PDZ-binding motif;    TEADs;    transcriptional enhancer associate domain transcription factors;    TFs;    transcription factors;    TGF;    transforming growth factor;    YAP;    Yes-associated protein;    Hippo pathway;    Oral development;    Maxillofacial development;    Bone remodeling;   

DOI  :  10.1016/j.ydbio.2018.05.017

学科分类：生物科学（综合）

来源: Academic Press

【 摘 要 】

The Hippo signaling pathway is implicated in key aspects of cell proliferation, control of organ size, stem cell functions and tumor suppression. Its functions are primarily mediated either through direct effects on transcription factors to influence target gene expression or through crosstalk with other signaling pathways that regulate multiple physiological activities. Studies are revealing Hippo pathway involvement in diverse functions including renewal of intestinal epithelium, promotion of myocardial cell proliferation, cancer suppression, etc. In this review we discuss Hippo pathway signaling in oral-maxillofacial development and bone remodeling under normal and pathological conditions and highlight promising future research directions.

【 授权许可】

CC BY